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Research Article

Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair

    Chun Liu

    *Author for correspondence:

    E-mail Address: ibptlc@fzu.edu.cn

    Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China

    ,
    Yun Li

    Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China

    ,
    Zhijian Yang

    College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China

    ,
    Zhiyou Zhou

    Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China

    ,
    Zhihao Lou

    Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China

    &
    Qiqing Zhang

    Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China

    Published Online:https://doi.org/10.2217/nnm-2019-0208

    The effectiveness of mesenchymal stem cells (MSC) in the treatment of cartilage diseases has been demonstrated to be attributed to the paracrine mechanisms, especially the mediation of exosomes. But the exosomes derived from unsynchronized MSCs may be nonhomogeneous and the therapeutic effect varies between samples. Aim: To produce homogeneous and more effective exosomes for the regeneration of cartilage. Materials & methods: In this study we produced specific exosomes from bone marrow MSCs (BMSC) through kartogenin (KGN) preconditioning and investigated their performance in either in vitro or in vivo experiments. Results & conclusion: The exosomes derived from KGN-preconditioned BMSCs (KGN-BMSC-Exos) performed more effectively than the exosomes derived from BMSCs (BMSC-Exos). KGN preconditioning endowed BMSC-Exos with stronger chondral matrix formation and less degradation.

    Papers of special note have been highlighted as: • of interest

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