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Short Communication

Anticancer palladium-doped magnesia nanoparticles: synthesis, characterization, and in vitro study

    Mohamed Qasim Al-Fahdawi

    Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, 43400, UPM, Malaysia

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    ,
    Abdullah Rasedee

    *Author for correspondence: Tel.: +603 9769 3445; Fax: +603 9769 1971;

    E-mail Address: rasedee@upm.edu.my

    Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, 43400, UPM, Malaysia

    Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, 43400, UPM, Malaysia

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    ,
    Faris AJ Al-Doghachi

    Department of Chemistry, Faculty of Science, University of Basra, Basra, Iraq

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    ,
    Rozita Rosli

    Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, 43400, UPM, Malaysia

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    ,
    Yun Hun Taufiq-Yap

    Catalysis Science & Technology Research Centre, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, 43400, UPM, Malaysia

    Department of Chemistry, Faculty of Science; Universiti Putra Malaysia, Serdang, Selangor, 43400, UPM, Malaysia

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    &
    Mothanna Sadiq Al-Qubaisi

    Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, 43400, UPM, Malaysia

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    Published Online:17 Feb 2020https://doi.org/10.2217/nnm-2019-0178

    Abstract

    Aim: To prepare, physicochemically characterize and determine the anticancer effects of palladium-doped magnesia (Pd/MgO) nanoparticles. Materials & methods: Pd/MgO nanoparticles were prepared by the co-precipitation method from the aqueous solution of Mg(NO3)2.6H2O using K2CO3 and the impregnation of MgO into palladium acetylacetonate. Results: Pd/MgO nanoparticles were between 47 and 70 nm in size, cuboid in shape, and tended to form aggregates. Nanoparticles were more antiproliferative toward cancer than the normal cells. In cancer cells, Pd/MgO nanoparticles induced apoptosis by increasing caspase activities and stimulating cytochrome C release. The anticancer effects of Pd/MgO nanoparticles were accentuated by the upregulation of Bax and p53 and downregulation of Bcl-2 protein expressions. Conclusion: Pd/MgO nanoparticles have potential to be developed as an anticancer compound.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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