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Research Article

Immunoactive polysaccharide functionalized gold nanocomposites promote dendritic cell stimulation and antitumor effects

    Guibin Pang

    Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China

    Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201210, PR China

    ,
    Shulei Zhang

    Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China

    Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201210, PR China

    ,
    Xiapeng Zhou

    Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, PR China

    ,
    Huan Yu

    School for Radiological & Interdisciplinary Sciences (RAD-X), State Key Laboratory of Radiation Medicine & Protection, School of Radiation Medicine & Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, PR China

    ,
    Yanxian Wu

    School for Radiological & Interdisciplinary Sciences (RAD-X), State Key Laboratory of Radiation Medicine & Protection, School of Radiation Medicine & Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, PR China

    ,
    Tianyan Jiang

    School for Radiological & Interdisciplinary Sciences (RAD-X), State Key Laboratory of Radiation Medicine & Protection, School of Radiation Medicine & Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, PR China

    ,
    Xihui Zhang

    School for Radiological & Interdisciplinary Sciences (RAD-X), State Key Laboratory of Radiation Medicine & Protection, School of Radiation Medicine & Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, PR China

    ,
    Fujun Wang

    *Author for correspondence: Tel.: +86 21 5132 2515;

    E-mail Address: wfj@shutcm.edu.cn

    Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China

    Zhejiang Reachall Pharmaceutical Co., Ltd., Dongyang, Zhejiang, 322100, PR China

    Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201210, PR China

    ,
    Yangyun Wang

    **Author for correspondence: Tel.: +86 512 6588 2942;

    E-mail Address: yywang578@suda.edu.cn

    School for Radiological & Interdisciplinary Sciences (RAD-X), State Key Laboratory of Radiation Medicine & Protection, School of Radiation Medicine & Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, PR China

    &
    Leshuai W Zhang

    ***Author for correspondence: Tel.: +86 512 6588 2942;

    E-mail Address: zhangls@suda.edu.cn

    School for Radiological & Interdisciplinary Sciences (RAD-X), State Key Laboratory of Radiation Medicine & Protection, School of Radiation Medicine & Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, PR China

    Zhejiang Reachall Pharmaceutical Co., Ltd., Dongyang, Zhejiang, 322100, PR China

    Published Online:https://doi.org/10.2217/nnm-2018-0390

    Aim: To investigate the immune responses and antitumor efficacy of immunoactive polysaccharide functionalized gold nanocomposites (APS-AuNP). Materials & methods: Immunoregulation of APS-AuNP on dendritic cells/T cells in vitro was evaluated by flow cytometry and their inhibitions against primary/metastatic tumors were determined on 4T1-bearing mice model. Results & conclusion: APS-AuNP exhibited remarkable capability to induce dendritic cells maturation through phenotypic markers with functional changes, which further promoted T-cell proliferation and enhanced cytotoxicity against 4T1 tumor cells. The inhibitory rate of APS-AuNP against 4T1 primary tumor growth and pulmonary metastasis in mice was higher than paclitaxel-treated group. In addition, APS-AuNP exhibited strong capability to increase the population of CD4+/CD8+ T lymphocytes as well as effector memory cells rather than central memory cells.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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