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Research Article

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

    Zhen Li

    College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Jialong Fan

    College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Chunyi Tong

    College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China

    ‡Authors contributed equally

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    ,
    Hongyan Zhou

    College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China

    ,
    Wenmiao Wang

    College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China

    ,
    Bin Li

    TCM & Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China

    ,
    Bin Liu

    *Author for correspondence: Tel.: +86 731 8972 0939; Fax: +86 731 8972 0939;

    E-mail Address: binliu2001@hotmail.com

    College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China

    &
    Wei Wang

    **Author for correspondence:

    E-mail Address: wangwei402@hotmail.com

    TCM & Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China

    Published Online:https://doi.org/10.2217/nnm-2018-0378

    Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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