Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1 El-Serag HB. Hepatocellular carcinoma. N. Engl. J. Med. 365(12), 1118–1127 (2011).
  Medline CASGoogle Scholar
• 2 Kumar V, Bhatt PC, Rahman M, Al-Abbasi FA, Anwar F, Verma A. Umbelliferon-α- d -glucopyranosyl-(2 I → 1 II)-α-Dglucopyranoside ameliorates diethylnitrosamine induced precancerous lesion development in liver via regulation of inflammation, hyperproliferation and antioxidant at preclinical stage. Biomed. Pharmacother. 94, 834–842 (2017). • An overview article on the use of poly(lactic co-glycolic acid) nanoparticles for hepatic cancer.
  Medline CASGoogle Scholar
• 3 El-Serag HB. Hepatocellular carcinoma. N. Engl. J. Med. 365(12), 1118–1127 (2011). • Provides details on hepatocellular carcinoma and its variants.
  Medline CASGoogle Scholar
• 4 Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet 379(9822), 1245–1255 (2012).
  MedlineGoogle Scholar
• 5 Befeler AS, Di Bisceglie AM. Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology 122(6), 1609–1619 (2002).
  MedlineGoogle Scholar
• 6 Anwar F, Al-Abbasi FA, Bhatt PC, Ahmad A, Sethi N, Kumar V. Umbelliferone β-D-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-κB. Toxicol. Res. (Camb.) 4(5), 1308–1323 (2015).
  CASGoogle Scholar
• 7 Verma A, Ahmed B, Anwar F et al. Novel glycoside from Wedelia calendulacea inhibits diethylnitrosamine-induced renal cancer via downregulating the COX-2 and PEG2 through nuclear factor-κB pathway. Inflammopharmacology 25(1), 159–175 (2017).
  Medline CASGoogle Scholar
• 8 Jang M, Cai L, Udeani GO et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275(5297), 218–220 (1997).
  Medline CASGoogle Scholar
• 9 Sticher O. Natural product isolation. Nat. Prod. Rep. 25(3), 517–554 (2008).
  Medline CASGoogle Scholar
• 10 Pandey P, Bhatt PC, Rahman M et al. Preclinical renal chemo-protective potential of Prunus amygdalus Batsch seed coat via alteration of multiple molecular pathways. Arch. Physiol. Biochem. 3455, 1–9 (2017).
  Google Scholar
• 11 Rahman M, Ahmad MZ, Kazmi I et al. Advancement in multifunctional nanoparticles for the effective treatment of cancer. Expert Opin. Drug Deliv. 9(4), 367–381 (2012). • Describes polymeric nanoparticles in cancer application.
  Medline CASGoogle Scholar
• 12 Rahman M, Ahmad MZ, Kazmi I et al. Emergence of nanomedicine as cancer targeted magic bullets: recent development and need to address the toxicity apprehension. Curr. Drug Discov. Technol. 9(4), 319–329 (2012).
  Medline CASGoogle Scholar
• 13 Yallapu MM, Gupta BK, Jaggi M, Chauhan SC. Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J. Colloid Interface Sci. 351(1), 19–29 (2010). •• Demonstrates the encapsulation of herbal drugs into poly(lactic co-glycolic acid) nanoparticles.
  Medline CASGoogle Scholar
• 14 Budhian A, Siegel SJ, Winey KI. Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol. J. Microencapsul. 22(7), 773–785 (2005).
  Medline CASGoogle Scholar
• 15 Tang X, Liang Y, Feng X, Zhang R, Jin X, Sun L. Co-delivery of docetaxel and poloxamer 235 by PLGA-TPGS nanoparticles for breast cancer treatment. Mater. Sci. Eng. C 49, 348–355 (2015).
  Medline CASGoogle Scholar
• 16 Bhattacherjee A, Dhara K, Chakraborti AS. Argpyrimidine-tagged rutin-encapsulated biocompatible (ethylene glycol dimers) nanoparticles: synthesis, characterization and evaluation for targeted drug delivery. Int. J. Pharm. 509(1–2), 507–517 (2016). •• Specifically describes synthesis, characterization methods and their evaluation method.
  Medline CASGoogle Scholar
• 17 Ahmad N, Ahmad R, Naqvi AA et al. Rutin-encapsulated chitosan nanoparticles targeted to the brain in the treatment of cerebral ischemia. Int. J. Biol. Macromol. 91, 640–655 (2016).
  Medline CASGoogle Scholar
• 18 Zheng G, Zhao R, Xu A, Shen Z, Chen X, Shao J. Co-delivery of sorafenib and siVEGF based on mesoporous silica nanoparticles for ASGPR mediated targeted HCC therapy. Eur. J. Pharm. Sci. 111, 492–502 (2018).
  Medline CASGoogle Scholar
• 19 Jiang K, Chi T, Li T et al. A smart pH-responsive nanocarrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways. Nanoscale 9(27), 9428–9439 (2017).
  Medline CASGoogle Scholar
• 20 Shan D, Zhang C, Kalaba S et al. Flexible biodegradable citrate-based polymeric step-index optical fiber. Biomaterials 143, 142–148 (2017).
  Medline CASGoogle Scholar
• 21 Zheng G, Shen Y, Zhao R et al. Dual-targeting multifuntional mesoporous silica nanocarrier for codelivery of siRNA and ursolic acid to folate receptor overexpressing cancer cells. J. Agric. Food Chem. 65(32), 6904–6911 (2017).
  Medline CASGoogle Scholar
• 22 Rodriguez Amado JR, Prada AL, Duarte JL et al. Development, stability and in vitro delivery profile of new loratadine-loaded nanoparticles. Saudi Pharm. J. 25(8), 1158–1168 (2017). •• Describes the stability of nanoparticles.
  MedlineGoogle Scholar
• 23 Anwar F, Mushtaq G, Kazmi I et al. Anticancer effect of rosiglitazone in rats treated with N-nitrosodiethylamine via inhibition of DNA synthesis: an implication for hepatocellular carcinoma. RSC Adv. 5(84), 68385–68391 (2015).
  CASGoogle Scholar
• 24 Khan R, Kazmi I, Afzal M et al. Fixed dose combination therapy loperamide and niacin ameliorates diethylnitrosamine-induced liver carcinogenesis in albino Wistar rats. RSC Adv. 5(83), 67996–68002 (2015).
  CASGoogle Scholar
• 25 Afzal M, Kazmi I, Khan R et al. Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism. Arch. Biochem. Biophys. 623–624, 58–63 (2017). •• Discusses the hepatic cancer-inducing mechanism.
  Medline CASGoogle Scholar
• 26 Verma A, Singh D, Anwar F, Bhatt PC, Al-Abbasi FA, Kumar V. Triterpenoids principle of Wedelia calendulacea attenuated diethynitrosamine-induced hepatocellular carcinoma via downregulating oxidative stress, inflammation and pathology via NF-kB pathway. Inflammopharmacology 26(1), 133–146 (2017).
  MedlineGoogle Scholar
• 27 Verma A, Bhatt PC, Kaithwas G et al. Chemomodulatory effect Melastoma malabathricum Linn against chemically induced renal carcinogenesis rats via attenuation of inflammation, oxidative stress and early markers of tumor expansion. Inflammopharmacology 24(5), 233–251 (2016).
  Medline CASGoogle Scholar
• 28 Kumar V, Al-Abbasi FA, Ahmed D, Verma A, Mujeeb M, Anwar F. Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE₂ and COX-2 expression via nuclear factor-κB. Food Funct. 6(5), 1652–1666 (2015).
  Medline CASGoogle Scholar
• 29 Kumar V, Ahmed D, Gupta PS, Anwar F, Mujeeb M. Antidiabetic, antioxidant and antihyperlipidemic activities of Melastoma malabathricum Linn. leaves in streptozotocin induced diabetic rats. BMC Complement. Altern. Med. 13(1), 222 (2013).
  MedlineGoogle Scholar
• 30 Kumar V, Bhatt PC, Rahman M et al. Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response. BMC Complement. Altern. Med. 16(1), 510 (2016).
  MedlineGoogle Scholar
• 31 Kumar V, Bhatt PC, Kaithwas G et al. α-mangostin mediated pharmacological modulation of hepatic carbohydrate metabolism in diabetes induced Wistar rat. Beni-Suef Univ. J. Basic Appl. Sci. 5(3), 255–276 (2016).
  Google Scholar
• 32 Thulasidasan AKT, Retnakumari AP, Shankar M et al. Folic acid conjugation improves the bioavailability and chemosensitizing efficacy ofcurcumin-encapsulated PLGA-PEG nanoparticles towards paclitaxel chemotherapy. Oncotarget 8(64), 107374–107389 (2017).
  MedlineGoogle Scholar
• 33 Lozoya-Agullo I, Araújo F, González-Álvarez I et al. PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen. Eur. J. Pharm. Sci. 115, 119–125 (2017).
  MedlineGoogle Scholar
• 34 Tolba R, Kraus T, Liedtke C, Schwarz M, Weiskirchen R. Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Lab. Anim. 49(1 Suppl.), 59–69 (2015).
  Medline CASGoogle Scholar
• 35 Ghosh A, Ghosh D, Sarkar S, Mandal AK, Thakur Choudhury S, Das N. Anticarcinogenic activity of nanoencapsulated quercetin in combating diethylnitrosamine-induced hepatocarcinoma in rats. Eur. J. Cancer Prev. 21(1), 32–41 (2012).
  Medline CASGoogle Scholar
• 36 Ghosh D, Choudhury ST, Ghosh S et al. Nanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat. Chem. Biol. Interact. 195(3), 206–214 (2012).
  Medline CASGoogle Scholar
• 37 Thi Thanh Thuy L, Morita T, Yoshida K et al. Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Am. J. Pathol. 179(2), 1050–1060 (2011).
  MedlineGoogle Scholar
• 38 Iqbal J, Minhajuddin M, Beg ZH. Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. Eur. J. Cancer Prev. 13(6), 515–520 (2004).
  Medline CASGoogle Scholar
• 39 Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc. Natl Acad. Sci. USA 103(28), 10544–10551 (2006).
  Medline CASGoogle Scholar
• 40 Fieten H, Hugen S, van den Ingh TSGAM et al. Urinary excretion of copper, zinc and iron with and without D-penicillamine administration in relation to hepatic copper concentration in dogs. Vet. J. 197(2), 468–473 (2013).
  Medline CASGoogle Scholar
• 41 Kumar V, Anwar F, Verma A, Mujeeb M. Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2^I→1^II)-α-D-glucopyranoside on adjuvant-induced arthritic rats. J. Food Sci. Technol. 52(6), 3402–3411 (2014).
  MedlineGoogle Scholar
• 42 Bhatt PC, Verma A, Al-Abbasi FA, Anwar F, Kumar V, Panda BP. Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of Aβ40 plaques in Alzheimer's disease. Int. J. Nanomed. 12, 8749–8768 (2017).
  Medline CASGoogle Scholar
• 43 Gayathri R, Kalpana Deepa Priya D, Gunassekaran GR, Sakthisekaran D. Protective role of ursolic acid in den induced oxidative stress mediated hepatocellular carcinoma – a focus on thiol status. Int. J. Pharm. Pharmacol. Sci. 2(Suppl. 4), 140–146 (2010).
  CASGoogle Scholar
• 44 Langeswaran K, Jagadeesan AJ, Balasubramanian MP. Modulation of membrane bound ATPases and metabolizing enzymes against n-nitosodiethylamine (DEN) induced primary liver cancer in wistar albino rats. Int. J. Pharma Bio Sci. 3(2), P156–P165 (2012).
  CASGoogle Scholar
• 45 Kamboj SS, Chopra K, Sandhir R. Hyperglycemia-induced alterations in synaptosomal membrane fluidity and activity of membrane bound enzymes: beneficial effect of N-acetylcysteine supplementation. Neuroscience 162(2), 349–358 (2009).
  Medline CASGoogle Scholar
• 46 Langeswaran K, Revathy R, Kumar SG, Vijayaprakash S, Balasubramanian MP. Kaempferol ameliorates aflatoxin B1 (AFB1) induced hepatocellular carcinoma through modifying metabolizing enzymes, membrane bound ATPases and mitochondrial TCA cycle enzymes. Asian Pac. J. Trop. Biomed. 2(3), S1653–S1659 (2012).
  Google Scholar
• 47 Balamurugan K, Karthikeyan J. Evaluation of luteolin in the prevention of N-nitrosodiethylamine-induced hepatocellular carcinoma using animal model system. Indian J. Clin. Biochem. 27(2), 157–163 (2012).
  Medline CASGoogle Scholar
• 48 Steensberg A, Keller C, Starkie RL, Osada T, Febbraio MA, Pedersen BK. IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 283(6), E1272–E1278 (2002).
  Medline CASGoogle Scholar
• 49 Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1 and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75(1), 40–47 (1990).
  Medline CASGoogle Scholar
• 50 Uehara T, Pogribny IP, Rusyn I. The DEN and CCl4 -induced mouse model of fibrosis and inflammation-associated hepatocellular carcinoma. Curr. Protoc. Pharmacol. 66, 1–10 (2014).
  MedlineGoogle Scholar
• 51 Leng T, Liu N, Dai Y et al. Dissection of DEN-induced platelet proteome changes reveals the progressively dysregulated pathways indicative of hepatocarcinogenesis. J. Proteome Res. 9(12), 6207–6219 (2010).
  Medline CASGoogle Scholar
• 52 Barashi N, Weiss ID, Wald O et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology 58(3), 1021–1030 (2013).
  Medline CASGoogle Scholar
• 53 Yu LX, Yan HX, Liu Q et al. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology 52(4), 1322–1333 (2010).
  Medline CASGoogle Scholar
• 54 Zhang HL, Yu LX, Yang W et al. Profound impact of gut homeostasis on chemically-induced protumorigenic inflammation and hepatocarcinogenesis in rats. J. Hepatol. 57(4), 803–812 (2012).
  MedlineGoogle Scholar
• 55 Ong ZY, Gibson RJ, Bowen JM et al. Proinflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis. Radiat. Oncol. 5, 22 (2010).
  MedlineGoogle Scholar
• 56 Kumar V, Bhatt PC, Rahman M et al. Fabrication, optimization and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies. Int. J. Nanomed. 12, 6747–6758 (2017).
  Medline CASGoogle Scholar
• 57 Liu Y, Liu M, Li B et al. Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model. Nutr. Metab. (Lond.) 7(1), 84 (2010).
  Google Scholar
• 58 Yang J, Guo J, Yuan J. In vitro antioxidant properties of rutin. Food Sci. Technol. 41(6), 1060–1066 (2008).
  CASGoogle Scholar