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Objectively measured sedentary behavior and brain volumetric measurements in multiple sclerosis

    Rachel E Klaren

    *Author for correspondence:

    E-mail Address: klaren2@illinois.edu

    Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

    ,
    Elizabeth A Hubbard

    Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

    ,
    Nathan C Wetter

    Jump Trading Stimulation & Education Center, Peoria, IL 61603, USA

    ,
    Bradley P Sutton

    Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

    &
    Robert W Motl

    Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35233, USA

    Published Online:https://doi.org/10.2217/nmt-2016-0036

    Aim: This study examined the association between sedentary behavior patterns and whole brain gray matter (GM), white matter (WM) and subcortical GM structures in persons with multiple sclerosis (MS). Methods: 36 persons with MS wore an accelerometer and underwent a brain MRI. Whole brain GM and WM and deep GM structures were calculated from 3D T1-weighted structural brain images. Results: There were statistically significant (p < 0.01) and moderate or large associations between number of sedentary bouts/day and brain volume measures. The primary result was a consistent negative association between number of sedentary bouts/day and whole brain GM and WM, and deep GM structures. Conclusion: We provide novel evidence for decreased brain volume as a correlate of a sedentary behavior pattern in persons with MS.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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