We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Janus kinase inhibitors: a future all-rounder in axial spondyloarthritis?

    Jin-Xian Huang

    Division of Rheumatology, Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, 518053, China

    &
    James Cheng-Chung Wei

    *Author for correspondence:

    E-mail Address: jccwei@gmail.com

    Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan

    Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan

    Graduate Institute of Integrated Medicine, China Medical University, Taichung, 40201, Taiwan

    Published Online:https://doi.org/10.2217/imt-2023-0176
    Free first page

    References

    • 1. Ramiro S, Nikiphorou E, Sepriano A et al. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update. Ann. Rheum. Dis. 82(1), 19–34 (2023).
    • 2. Deodhar A, Sliwinska-Stanczyk P, Xu H et al. Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study. Ann. Rheum. Dis. 80(8), 1004–1013 (2021).
    • 3. van der Heijde D, Baraliakos X, Gensler LS et al. Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial. Lancet 392(10162), 2378–2387 (2018).
    • 4. van der Heijde D, Song IH, Pangan AL et al. Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial. Lancet 394(10214), 2108–2117 (2019).
    • 5. Deodhar A, Van den Bosch F, Poddubnyy D et al. Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 400(10349), 369–379 (2022).
    • 6. van der Heijde D, Baraliakos X, Sieper J et al. Efficacy and safety of upadacitinib for active ankylosing spondylitis refractory to biological therapy: a double-blind, randomised, placebo-controlled phase 3 trial. Ann. Rheum. Dis. 81(11), 1515–1523 (2022).
    • 7. Deodhar A, van der Heijde D, Sieper J et al. Safety and efficacy of upadacitinib in patients with active ankylosing spondylitis and an inadequate response to nonsteroidal antiinflammatory drug therapy: one-year results of a double-blind, placebo-controlled study and Open-label extension. Arthritis Rheumatol. 74(1), 70–80 (2022).
    • 8. van der Heijde D, Deodhar A, Maksymowych WP et al. Upadacitinib in active ankylosing spondylitis: results of the 2-year, double-blind, placebo-controlled SELECT-AXIS 1 study and open-label extension. RMD Open 8(2), e002280 (2022).
    • 9. Lasa JS, Olivera PA, Danese S, Peyrin-Biroulet L. Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis. Lancet Gastroenterol. Hepatol. 7(2), 161–170 (2022).
    • 10. Sandborn WJ, Feagan BG, Loftus EV Jr et al. Efficacy and safety of upadacitinib in a randomized trial of patients with Crohn's disease. Gastroenterology 158(8), 2123–2138; e8 (2020).
    • 11. Harkins P, Burke E, Swales C, Silman A, Conway R. Are Janus kinase inhibitors safe and effective in treating the key clinical domains of psoriatic arthritis? A systematic review and meta-analysis. Int. J. Rheum. Dis. 26(1), 31–42 (2023).
    • 12. Foeldvari I, Maccora I, Petrushkin H et al. New and updated recommendations for the treatment of juvenile idiopathic arthritis-associated uveitis and idiopathic chronic anterior uveitis. Arthritis Care Res. (Hoboken) 75(5), 975–982 (2023).
    • 13. Hecquet S, Valnet Rabier MB, Lepelley M et al. Ophthalmic adverse events under tofacitinib and baricitinib: case analysis of the European Pharmacovigilance Database. Joint Bone Spine 90(1), 105483 (2023).
    • 14. Maccora I, Land P, Miraldi Utz V, Angeles-Han ST. Therapeutic potential of JAK inhibitors in juvenile idiopathic arthritis-associated uveitis. Expert Rev. Clin. Immunol. 19(7), 689–692 (2023).
    • 15. Schneider J, Schalenbourg A, Dudler J, Guex-Crosier Y. Intermediate uveitis in an HLA-B27-positive patient treated with upadacitinib. Klin. Monbl. Augenheilkd. 239(4), 572–574 (2022).
    • 16. Joo W, Almario CV, Ishimori M et al. Examining treatment decision-making among patients with axial spondyloarthritis: insights from a conjoint analysis survey. ACR Open Rheumatol. 2(7), 391–400 (2020).
    • 17. Lee SH, Kim YG, Lee SG et al. Treatment pattern, satisfaction, and productivity loss of patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors in Korea: a multicenter cross-sectional observational study. Int. J. Rheum. Dis. 25(5), 523–531 (2022).
    • 18. Nash P, Kerschbaumer A, Dörner T et al. Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement. Ann. Rheum. Dis. 80(1), 71–87 (2021).
    • 19. Fang YF, Liu JR, Chang SH, Kuo CF, See LC. Comparative safety of Janus kinase inhibitors and tumor necrosis factor inhibitors in patients undergoing treatment for rheumatoid arthritis. Int. J. Rheum. Dis. 25(11), 1254–1262 (2022).
    • 20. Burmester GR, Cohen SB, Winthrop KL et al. Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis. RMD Open 9(1), e002735 (2023).