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Systematic Review

Amalgamation of nanotechnology with chicken IgY to enrich therapeutic and diagnostic applications: a systematic review

    Laksha Gayathri Suresh

    Bioengineering, School of Chemical & Biotechnology, SASTRA Deemed-to-be-University, Thanjavur, Tamil Nadu, 613401, India

    ,
    Srichandrasekar Thuthikkadu Indhuprakash

    Bioengineering, School of Chemical & Biotechnology, SASTRA Deemed-to-be-University, Thanjavur, Tamil Nadu, 613401, India

    Centre for Research in Infectious Diseases (CRID), School of Chemical & Biotechnology, SASTRA Deemed-to-be-University, Thanjavur, Tamil Nadu, 613401, India

    ,
    Sakthivel Gandhi

    Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical & Biotechnology, SASTRA Deemed-to-be-University, Thanjavur, Tamil Nadu, 613401, India

    &
    Thirumalai Diraviyam

    *Author for correspondence: Tel.: +91 436 226 4101 108;

    E-mail Address: diraviyam@scbt.sastra.edu

    Bioengineering, School of Chemical & Biotechnology, SASTRA Deemed-to-be-University, Thanjavur, Tamil Nadu, 613401, India

    Centre for Research in Infectious Diseases (CRID), School of Chemical & Biotechnology, SASTRA Deemed-to-be-University, Thanjavur, Tamil Nadu, 613401, India

    Published Online:

    Aim: The article explores the possibility of using nanoparticles and IgY technology together for biosensing and antibody delivery to fight mammalian infections. The use of IgG in passive immunotherapy has drawbacks; however, nanoparticles and IgY technology offer new opportunities for diagnostic and therapeutic applications. Methods: The primary selection of reports was based on the title and abstract, and potential studies were selected based on predefined inclusion criteria such as nanoparticle/nanomaterials and IgY, studies that have employed nanoparticles–IgY for diagnostic and therapeutic applications and animal experiments. Results: Nanoparticle–IgY conjugates have great potential in diagnostics and therapeutics, but translation of nanotechnology-based IgY technology from laboratory settings to clinical setup is still a challenge. As science advances, nanoimmunotherapy can be explored in modern-day medicine.

    Plain language summary

    The human body makes proteins, called antibodies, that fight germs. Scientists use chickens and their eggs to make these proteins for treating diseases. If antibodies are used to treat diseases in the stomach, they can get damaged, but they can be protected with nanoparticles. They protect the proteins from degradation and deliver them safely to the target place. Thus, scientists use this combination to treat infections. The same combination also helps detect the germs.

    Graphical abstract

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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