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Current immunosuppression strategies in pediatric heart transplant

    Konstantinos S Mylonas

    *Author for correspondence: Tel.: +3069 8702 4653;

    E-mail Address: ksmylonas@gmail.com

    Department of Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece

    ,
    Ioanna Soukouli

    Department of Nephrology & Renal Transplantation, Laiko General Hospital, National & Kapodistrian University of Athens, Athens, Greece

    ,
    Dimitrios V Avgerinos

    Department of Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece

    &
    John N Boletis

    Department of Nephrology & Renal Transplantation, Laiko General Hospital, National & Kapodistrian University of Athens, Athens, Greece

    Published Online:https://doi.org/10.2217/imt-2021-0352
    Free first page

    References

    • 1. Kirk R, Edwards LB, Aurora P et al. Registry of the International Society for Heart and Lung Transplantation: Twelfth Official Pediatric Heart Transplantation Report-2009. J. Heart Lung Transplant. 28(10), 993–1006 (2009).
    • 2. Canter CE, Shaddy RE, Bernstein D et al. Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on cardiovascular disease in the young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 115(5), 658–676 (2007).
    • 3. Di Filippo S, Boissonnat P, Sassolas F et al. Rabbit antithymocyte globulin as induction immunotherapy in pediatric heart transplantation. Transplantation 75(3), 354–358 (2003).
    • 4. Irving CA, Webber SA. Immunosuppression therapy for pediatric heart transplantation. Curr. Treat. Options Cardiovasc. Med. 12(5), 489–502 (2010).
    • 5. Butts RJ, Dipchand AI, Sutcliffe D et al. Comparison of basiliximab vs antithymocyte globulin for induction in pediatric heart transplant recipients: an analysis of the International Society for Heart and Lung Transplantation database. Pediatr. Transplant. 22(4), e13190 (2018).
    • 6. Cochrane AB, Lyster H, Lindenfeld J et al. Report from the 2018 consensus conference on immunomodulating agents in thoracic transplantation: access, formulations, generics, therapeutic drug monitoring, and special populations. J. Heart Lung Transplant. 39(10), 1050–1069 (2020).
    • 7. Simmonds J, Dewar C, Dawkins H, Burch M, Fenton M. Tacrolimus in pediatric heart transplantation: ameliorated side effects in the steroid-free, statin era. Clin. Transplant. 23(3), 415–419 (2009).
    • 8. Robinson BV, Boyle GJ, Miller SA et al. Optimal dosing of intravenous tacrolimus following pediatric heart transplantation. J. Heart Lung Transplant. 18(8), 786–791 (1999).
    • 9. D'addese L, Joong A, Burch M, Pahl E. Pediatric heart transplantation in the current era. Curr. Opin. Pediatr. 31(5), 583–591 (2019).
    • 10. Eisen HJ, Kobashigawa J, Keogh A et al. Three-year results of a randomized, double-blind, controlled trial of mycophenolate mofetil versus azathioprine in cardiac transplant recipients. J. Heart Lung Transplant. 24(5), 517–525 (2005).
    • 11. Gajarski RJ, Crowley DC, Zamberlan MC, Lake KD. Lack of correlation between MMF dose and MPA level in pediatric and young adult cardiac transplant patients: does the MPA level matter? Am. J. Transplant. 4(9), 1495–1500 (2004).
    • 12. Gustafsson F, Andreassen AK, Andersson B et al. Everolimus initiation with early calcineurin inhibitor withdrawal in de novo heart transplant recipients: long-term follow-up from the randomized SCHEDULE study. Transplantation 104(1), 154–164 (2020).
    • 13. Raichlin E, Bae JH, Khalpey Z et al. Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation. Circulation 116(23), 2726–2733 (2007).
    • 14. Asante-Korang A, Carapellucci J, Krasnopero D, Doyle A, Brown B, Amankwah E. Conversion from calcineurin inhibitors to mTOR inhibitors as primary immunosuppressive drugs in pediatric heart transplantation. Clin. Transplant. 31(10), (2017).
    • 15. Rosenthal LM, Nordmeyer J, Kramer P et al. Long-term experience using CNI-free immunosuppression in selected paediatric heart transplant recipients. Pediatr. Transplant. 25(8), e14111 (2021).
    • 16. Smith RR, Wray J, Khaghani A, Yacoub M. Ten year survival after paediatric heart transplantation: a single centre experience. Eur. J. Cardiothorac. Surg. 27(5), 790–794 (2005).
    • 17. Singh TP, Faber C, Blume ED et al. Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant recipients. J. Heart Lung Transplant. 29(5), 517–522 (2010).
    • 18. Pollock-Barziv SM, Den Hollander N, Ngan BY et al. Pediatric heart transplantation in human leukocyte antigen sensitized patients: evolving management and assessment of intermediate-term outcomes in a high-risk population. Circulation 116(Suppl. 11), I172–178 (2007).
    • 19. Kaposztas Z, Podder H, Mauiyyedi S et al. Impact of rituximab therapy for treatment of acute humoral rejection. Clin. Transplant. 23(1), 63–73 (2009).
    • 20. Morrow WR, Frazier EA, Mahle WT et al. Rapid reduction in donor-specific anti-human leukocyte antigen antibodies and reversal of antibody-mediated rejection with bortezomib in pediatric heart transplant patients. Transplantation 93(3), 319–324 (2012).