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Research Article

Clinical relevance of antigen spreading pattern induced by CHP-MAGE-A4 cancer vaccination

    Kengo Miyauchi

    Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

    ,
    Takahiro Tsuchikawa

    *Author for correspondence:

    E-mail Address: tsuchi-t@med.hokudai.ac.jp

    Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

    ,
    Masataka Wada

    Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

    ,
    Takehiro Abiko

    Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

    ,
    Noriaki Kyogoku

    Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

    ,
    Toshiaki Shichinohe

    Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

    ,
    Yoshihiro Miyahara

    Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    ,
    Shinichi Kageyama

    Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    ,
    Hiroaki Ikeda

    Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    ,
    Hiroshi Shiku

    Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    &
    Satoshi Hirano

    Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

    Published Online:https://doi.org/10.2217/imt-2016-0007

    Aim: To investigate the antigen spreading pattern in the CHP-MAGE-A4-vaccinated patients and analyze the clinical relevance of antigen spreading pattern as a surrogate marker of patient survival. Materials & methods: 12 patients who had been injected with 300 μg of CHP-MAGE-A4 and 0.5 Klinische Einheit of OK-432 in more than five vaccinations were analyzed. Results: Increases in the anti-MAGE-A4-specific antibody response were observed in eight patients (66.7%), compared with six patients (50%) for anti-NY-ESO-1 and five patients (41.7%) for anti-MAGE-A3 after five vaccinations. We identified frequent antigen spreading following MAGE-A4 vaccinations without associations with the clinical response or patient prognosis. Conclusion: Antigen spreading pattern might reflect tumor shrinkage as a response to treatment and treatment history (clinical trial registration number: UMIN000001999).

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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