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Short Communication

Expression of miR-203 and its target genes in condyloma acuminatum and their relationships with clinical recurrence

    Beilei He

    Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310008, China

    ,
    Yangfan Wu

    Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310008, China

    ,
    Qingyun Yang

    Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310008, China

    ,
    Enyi Ye

    Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310008, China

    ,
    Tingkai Xiang

    Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310008, China

    ,
    Xinyi Wang

    Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310008, China

    ,
    Lin Deng

    Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310000, China

    ,
    Kune Lu

    Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310000, China

    ,
    Jue Liu

    Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310000, China

    ,
    Xiaohong Yu

    Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310000, China

    &
    Zhangyu Bu

    *Author for correspondence:

    E-mail Address: buzyhz@163.com

    Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310000, China

    Published Online:https://doi.org/10.2217/fvl-2023-0086

    Aim: To examine the expression of miR-203 and its target genes survivin and p63 in condyloma acuminatum (CA) and to determine their relationships with clinical recurrence. Methods: Case and control groups were assessed for general data and the expression levels of miR-203, survivin and p63. The case group received carbon dioxide laser treatment, had a 3-month follow-up period, and was then divided into recurrence and non-recurrence groups. The relevant data were analyzed using SPSS v. 25.0 software. Results:miR-203 was identified as an independent protective factor against the recurrence of CA, while wart number, survivin and p63 were independent risk factors for CA recurrence. Conclusion:miR-203 could be a specific clinical bioindicator for the prognosis and recurrence of CA.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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