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Short Communication

Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women

    Mostafa Salehi-Vaziri

    Department of Arboviruses and Viral Hemorrhagic Fever, Pasteur Institute of Iran, Tehran, Iran

    Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    ,
    Farzin Sadeghi

    Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Department of Immunology & Microbiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

    ,
    Hayedeh Haeri

    Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

    ,
    Farah Bokharaei-Salim

    Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    ,
    Seyed Hamidreza Monavari

    Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    ,
    Firoozeh Sadat Hashemi

    Department of Gynecology Oncology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

    ,
    Somayeh Jalilvand

    Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    &
    Hossein Keyvani

    *Author for correspondence: Tel.: +98 21 8860 2205;

    E-mail Address: Keyvanlab@yahoo.com

    Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Published Online:https://doi.org/10.2217/fvl-2022-0174

    Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16) and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16 variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based on our data, the predominant HPV16 lineage was D and there was a significant association between lineage D variants and cervical cancer.

    Tweetable abstract

    The intratypic variations of HPV16 were assessed in Iranian women with cervical cancer. HPV16 variants of 58 women were determined using PCR followed by directed sequencing. The most frequent lineage was D followed by A. This study revealed a distinct pattern of HPV16 variants in Iran.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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