Torque Teno virus and cancers: current knowledge

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1. Biagini P. Classification of TTV and related viruses (anelloviruses). Curr. Top. Microbial. Immunol. 331, 21–33 (2009).
  Medline CASGoogle Scholar
• 2. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem. Biophys. Res. Commun. 241(1), 92–97 (1997).
  Medline CASGoogle Scholar
• 3. Kaczorowska J, van der Hoek L. Human anelloviruses: diverse, omnipresent and commensal members of the virome. FEMS Microbiol. Rev. 44(3), 305–313 (2020).
  Medline CASGoogle Scholar
• 4. Okamoto H. History of discoveries and pathogenicity of TT viruses. Curr. Top. Microbiol. Immunol. 331, 1–20 (2009).
  Medline CASGoogle Scholar
• 5. Hsiao KL, Wang LY, Lin CL, Liu HF. New phylogenetic groups of Torque Teno Virus identified in Eastern Taiwan Indigenes. PLOS One. 11(2), e0149901 (2016).
  MedlineGoogle Scholar
• 6. Spandole S, Cimponeriu D, Berca LM, Mihaescu G. Human anelloviruses: an update of molecular, epidemiological and clinical aspects. Arch. Virol. 160(4), 893–908 (2015). • General introductory article that summarizes some specific aspects of the virus.
  Medline CASGoogle Scholar
• 7. Lapa D, Del Porto P, Minosse C et al. Clinical relevance of Torque Teno Virus (TTV) in HIV/HCV coinfected and HCV monoinfected patients treated with Direct-Acting Antiviral therapy. J. Clin. Med. 10(10), 2092 (2021).
  Medline CASGoogle Scholar
• 8. Liu H, Zhao J, Yang L, Yang C, Liu Y. An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus? Int. J. Infect. Dis. 115, 26–29 (2022).
  Medline CASGoogle Scholar
• 9. Batista AM, Caetano MW, Stincarelli MA et al. Quantification of torque teno virus (TTV) DNA in saliva and plasma samples in patients at short time before and after kidney transplantation. J. Oral. Microbiol. 14(1), 2008140 (2021).
  MedlineGoogle Scholar
• 10. Tozetto-Mendoza TR, Mendes-Correa MC, Moron AF et al. The vaginal Torquetenovirus titer varies with vaginal microbiota composition in pregnant women. PLOS One. 17(1), e0262672 (2022).
  Medline CASGoogle Scholar
• 11. Asim M, Singla R, Gupta RK, Kar P. Clinical & molecular characterization of human TT virus in different liver diseases. Indian J. Med. Res. 131, 545–554 (2010).
  Medline CASGoogle Scholar
• 12. Rodríguez-Iñigo E, Casqueiro M, Bartolomé J et al. Detection of TT virus DNA in liver biopsies by in situ hybridization. Am. J. Pathol. 156(4), 1227–1234 (2000).
  Medline CASGoogle Scholar
• 13. Kosulin K, Kernbichler S, Pichler H et al. Post-transplant replication of Torque Teno Virus in granulocytes. Front Microbiol. 9, 2956 (2018). • In this article the authors observed that observed that granulocyte recovery might be required for Torque teno virus (TTV) expansion in severely immunosuppressed transplant recipients.
  MedlineGoogle Scholar
• 14. Focosi D, Macera L, Boggi U, Nelli LC, Maggi F. Short-term kinetics of torque teno virus viraemia after induction immunosuppression confirm T lymphocytes as the main replication-competent cells. J. Gen. Virol. 96(Pt 1), 115–117 (2015).
  Medline CASGoogle Scholar
• 15. Dodi G, Attanasi M, Di Filippo P, Di Pillo S, Chiarelli F. Virome in the lungs: the role of Anelloviruses in childhood respiratory diseases. Microorganisms. 9(7), 1357 (2021).
  Medline CASGoogle Scholar
• 16. Focosi D, Antonelli G, Pistello M, Maggi F. Torquetenovirus: the human virome from bench to bedside. Clin. Microbiol. Infect. 22(7), 589–593 (2016).
  Medline CASGoogle Scholar
• 17. Nasser TF, Brajão de Oliveira K, Reiche EM, Amarante MK, Pelegrinelli Fungaro MH, Watanabe MA. Detection of TT virus in HIV-1 exposed but uninfected individuals and in HIV-1 infected patients and its influence on CD4+ lymphocytes and viral load. Microb. Pathog. 47(1), 33–37 (2009).
  Medline CASGoogle Scholar
• 18. Mrzljak A, Vilibic-Caviek T. Torque teno viruses in liver diseases and after liver transplantation. World J.Transplant. 10(11), 291–296 (2020). • In this article TTV viral load positively correlates with the intensity of immunosuppression
  MedlineGoogle Scholar
• 19. Xie Y, Xue Q, Jiao W et al. Associations between sputum torque teno virus load and lung function and disease severity in patients with chronic obstructive pulmonary disease. Front. Med. (Lausanne) 8, 618757 (2021).
  MedlineGoogle Scholar
• 20. Dibiaggi M, Zara F, Sacchi P et al. Transfusion-transmitted virus infection in HIV-1 seropositive patients. Clin. Microbiol. Infect. 6(5), 246–250 (2000).
  MedlineGoogle Scholar
• 21. Honorato L, Witkin SS, Mendes-Correa MC et al. The Torque Teno Virus Titer in saliva reflects the level of circulating CD4 + T Lymphocytes and HIV in individuals undergoing antiretroviral maintenance therapy. Front Med (Lausanne). 8, 809312 (2022).
  MedlineGoogle Scholar
• 22. Mendes-Correa MC, Tozetto-Mendoza TR, Freire WS et al. Torquetenovirus in saliva: a potential biomarker for SARS-CoV-2 infection? PLOS One. 16(8), e0256357 (2021). • In this article the authors proposed that TTV measurement in saliva is potentially useful to predict COVID-19 prognosis
  Medline CASGoogle Scholar
• 23. Forqué L, Albert E, Giménez E et al. Monitoring of Torque Teno virus DNAemia in critically ill COVID-19 patients: may it help to predict clinical outcomes? J Clin Virol. 148, 105082 (2022).
  Medline CASGoogle Scholar
• 24. Focosi D, Macera L, Pistello M, Maggi F. Torque Teno virus viremia correlates with intensity of maintenance immunosuppression in adult orthotopic liver transplant. J. Infect. Dis. 210(4), 667–668 (2014).
  MedlineGoogle Scholar
• 25. Bueno F, Albert E, Piñana JL et al. Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation. Transpl. Infect. Dis. 23(3), e13507 (2021).
  Medline CASGoogle Scholar
• 26. Fernández-Ruiz M, Forque L, Albert E et al. Human pegivirus type 1 infection in kidney transplant recipients: replication kinetics and clinical correlates. Transpl. Infect. Dis. 24(1), e13771 (2022).
  Medline CASGoogle Scholar
• 27. Jaksch P, Görzer I, Puchhammer-Stöckl E, Bond G. Integrated immunologic monitoring in solid organ transplantation: the road toward torque teno virus-guided immunosuppression. Transplantation 106(10), 1940–1951 (2022).
  Medline CASGoogle Scholar
• 28. Liberati A, Altman DG, Tetzlaff J et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLOS Med. 6(7), e1000100 (2009).
  MedlineGoogle Scholar
• 29. Wells GA, Shea B, O'Connell D et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Syst. Rev., Available online: https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp (Accessed on 22 August 2022).
  Google Scholar
• 30. Hettmann A, Demcsák A, Decsi G et al. Infectious agents associated with head and neck carcinomas. Adv. Exp. Med. Biol. 897, 63–80 (2016).
  MedlineGoogle Scholar
• 31. Spandole S, Cimponeriu D, Berca LM, Mihăescu G. Human anelloviruses: an update of molecular, epidemiological and clinical aspects. Arch. Virol. 160(4), 893–908 (2015).
  Medline CASGoogle Scholar
• 32. Kew MC. Hepatitis viruses (other than hepatitis B and C viruses) as causes of hepatocellular carcinoma: an update. J. Viral Hepat. 20(3), 149–157 (2013).
  Medline CASGoogle Scholar
• 33. zur Hausen H, de Villiers EM. TT Viruses: Oncogenic or Tumor-Suppressive Properties? Curr. Top. Microbiol. Immunol. 331, 109–116 (2009). • The authors suggested that TTV modulated T cell immune responses with an indirect carcinogen role
  Medline CASGoogle Scholar
• 34. Okamoto H. History of discoveries and pathogenicity of TT viruses. Curr. Top. Microbiol. Immunol. 331, 1–20 (2009).
  Medline CASGoogle Scholar
• 35. Hino S, Miyata H. Torque teno virus (TTV): current status. Rev. Med. Virol. 17(1), 45–57 (2007).
  Medline CASGoogle Scholar
• 36. Pescarmona R, Mouton W, Walzer T et al. Evaluation of TTV replication as a biomarker of immune checkpoint inhibitors efficacy in melanoma patients. PLOS One. 16(8), e0255972 (2021).
  Medline CASGoogle Scholar
• 37. Stefani D, Hegedues B, Collaud S et al. Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage. PLOS One. 16(6), e0252304 (2021).
  Medline CASGoogle Scholar
• 38. de Villiers EM, Bulajic M, Nitsch C et al. TTV infection in colorectal cancer tissues and normal mucosa. Int. J. Cancer 121(9), 2109–2112 (2007).
  Medline CASGoogle Scholar
• 39. Girard C, Ottomani L, Ducos J, Dereure O, Carles MJ, Guillot B. High Prevalence of Torque teno (TT) virus in classical Kaposi's sarcoma. Acta Derm. Venereol. 87(1), 14–17 (2007).
  Medline CASGoogle Scholar
• 40. Comar M, Dal Molin G, D'Agaro P, Crocè SL, Tiribelli C, Campello C. HBV, HCV, and TTV detection by in situ polymerase chain reaction could reveal occult infection in hepatocellular carcinoma: comparison with blood markers. J. Clin. Pathol. 59(5), 526–529 (2006).
  Medline CASGoogle Scholar
• 41. Szládek G, Juhász A, Kardos G et al. High co-prevalence of genogroup 1 TT virus and human papillomavirus is associated with poor clinical outcome of laryngeal carcinoma. J. Clin. Pathol. 58(4), 402–405 (2005).
  Medline CASGoogle Scholar
• 42. Camci C, Guney C, Balkan A et al. The prevalence of TT virus in cancer patients. New Microbiol. 25(4), 463–468 (2002).
  Medline CASGoogle Scholar
• 43. Tokita H, Murai S, Kamitsukasa H et al. High TT virus load as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus-related chronic liver disease. J. Med. Virol. 67(4), 501–509 (2002).
  MedlineGoogle Scholar
• 44. Yoshida H, Kato N, Shiratori Y et al. Poor association of TT virus viremia with hepatocellular carcinoma. Liver. 20(3), 247–252 (2000).
  Medline CASGoogle Scholar
• 45. Abed RM, Shamran HA, Ridha AA. Detection and genotyping of Torque Teno virus in saliva and tumor biopsies from patients with oral cancer. Ann. Trop. Med. Public Health. 23, 14 Article Number SP231412 (2020).
  Google Scholar
• 46. Tagger A, Donato F, Ribero ML et al. A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma. Hepatology 30(1), 294–299 (1999).
  Medline CASGoogle Scholar
• 47. Starzer AM, Mayer J, Haselboeck H et al. 1774P Exploration of torque teno virus (TTV) levels as marker for immune suppression during systemic therapy in advanced solid cancer patients. Ann. Oncol. 32(Suppl. 5), S1216 (2021).
  MedlineGoogle Scholar
• 48. Hassoba H, Mahmoud M, Fahmy H et al. TT virus infection among Egyptian patients with hepatocellular carcinoma. Egypt J. Immunol. 10(1), 9–16 (2003).
  MedlineGoogle Scholar
• 49. de Villiers EM, Schmidt R, Delius H, zur Hausen H. Heterogeneity of TT virus related sequences isolated from human tumour biopsy specimens. J. Mol. Med. (Berl). 80(1), 44–50 (2002).
  Medline CASGoogle Scholar
• 50. Zhong S, Yeo W, Tang M et al. Frequent detection of the replicative form of TT virus DNA in peripheral blood mononuclear cells and bone marrow cells in cancer patients. J. Med. Virol. 66(3), 428–434 (2002).
  Medline CASGoogle Scholar
• 51. Shimizu T, Moriyama M, Tanaka N, Arakawa Y. Persistent TT virus infection does not contribute to the development of non-A to -G hepatocellular carcinoma. A case-control study of 19 patients in Japan. Intervirology. 43(2), 80–86 (2000).
  Medline CASGoogle Scholar
• 52. Pineau P, Meddeb M, Raselli R et al. Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey. J. Infect. Dis. 181(3), 1138–1142 (2000).
  Medline CASGoogle Scholar
• 53. Kim SR, Hayashi Y, Kudo M et al. TTV positivity and transfusion history in non-B, non-C hepatocellular carcinoma compared with HBV- and HCV-positive cases. Intervirology. 43(1), 13–15 (2000).
  Medline CASGoogle Scholar
• 54. Sawata T, Bando M, Nakayama M et al. Clinical significance of changes in Torque teno virus DNA titer after chemotherapy in patients with primary lung cancer. Respir. Investig. 56(2), 173–178 (2018).
  MedlineGoogle Scholar
• 55. Rosa AS, Araujo OC, Savassi-Ribas F et al. Prevalence of occult hepatitis B virus infection and Torque teno virus infection and their association with hepatocellular carcinoma in chronic hepatitis C patients. Virus Res. 242, 166–172 (2017). • In this article the authors demonstrated that TTV infection was an independent factor associated with the diagnosis of hepatocellular carcinoma
  Medline CASGoogle Scholar
• 56. Bando M, Takahashi M, Ohno S et al. Torque teno virus DNA titre elevated in idiopathic pulmonary fibrosis with primary lung cancer. Respirology. 13(2), 263–269 (2008).
  MedlineGoogle Scholar
• 57. Hafez MM, Shaarawy SM, Hassan AA, Salim RF, Abd El Salam FM, Ali AE. Prevalence of transfusion transmitted virus (TTV) genotypes among HCC patients in Qaluobia governorate. Virol J. 4, 135 (2007).
  MedlineGoogle Scholar
• 58. Tomasiewicz K, Modrzewska R, Lyczak A, Krawczuk G. TT virus infection and pancreatic cancer: relationship or accidental coexistence. World J. Gastroenterol. 11(18), 2847–2849 (2005).
  MedlineGoogle Scholar
• 59. Toshikuni N, Kayano K, Nishioka S et al. TT virus-positive hepatocellular carcinoma arising from non-cirrhotic liver in an elderly man. Intern. Med. 42(12), 1172–1177 (2003).
  MedlineGoogle Scholar
• 60. Hettmann A, Demcsák A, Bach Á et al. Detection and phylogenetic analysis of Torque Teno Virus in salivary and tumor biopsy samples from head and neck carcinoma patients. Intervirology. 59(2), 123–129 (2016).
  Medline CASGoogle Scholar
• 61. Emmel V, Gama B, de Paula A, Ferreira G, Binato R, Abdelhay E. Can torque teno virus be a predictor of SARS-CoV-2 disease progression in cancer patients? J. Infect. Chemother. 28(12), 1623–1627 (2022).
  Medline CASGoogle Scholar
• 62. Changani L, Bouzari M, Talebi A. Torque teno mini virus infection in chronic cervicitis and cervical tumors in Isfahan, Iran. Intervirology. 56(4), 265–270 (2013).
  MedlineGoogle Scholar
• 63. Cai X, Zhan H, Ye Y et al. Current progress and future perspectives of immune checkpoint in cancer and infectious diseases. Front. Genet. 12, 785153 (2021). • This article focused on the role of immune checkpoints in microbial-infection disease
  Medline CASGoogle Scholar
• 64. Tyschik EA, Rasskazova AS, Degtyareva AV, Rebrikov DV, Sukhikh GT. Torque teno virus dynamics during the first year of life. Virol. J. 15(1), 96 (2018).
  MedlineGoogle Scholar
• 65. Fernández-Ruiz M. Torque Teno virus load as a surrogate marker for the net state of immunosuppression: the beneficial side of the virome. Am. J. Transplant. 20(8), 1963–1964 (2020).
  MedlineGoogle Scholar
• 66. Burra P, Masier A, Boldrin C et al. Torque Teno Virus: any pathological role in liver transplanted patients? Transpl. Int. 21(10), 972–979 (2008).
  MedlineGoogle Scholar
• 67. Lasagna A, Cassaniti I, Sacchi P, Baldanti F, Bruno R, Pedrazzoli P. Infectious complications and immunotherapy: old pitfalls and new horizons. Future Oncol. 18(22), 2377–2381 (2022).
  CASGoogle Scholar
• 68. Broecker F, Moelling K. The roles of the virome in cancer. Microorganisms. 9(12), 2538 (2021). •• This review summarizes the current knowledge on the human virome and its links to cancer
  Medline CASGoogle Scholar
• 69. Maggi F, Tempestini E, Lanini L et al. Blood levels of TT virus following immune stimulation with influenza or hepatitis B vaccine. J. Med. Virol. 75(2), 358–365 (2005).
  MedlineGoogle Scholar
• 70. Rezahosseini O, Nielsen SD. Torque-Teno virus to optimize timing of vaccination against severe acute respiratory syndrome coronavirus 2 in solid organ transplant recipients. J. Clin. Virol. 143, 104967 (2021).
  Medline CASGoogle Scholar