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Association between human herpesvirus-6 and primary brain tumors: a systematic review and meta-analysis

    Saied Ghorbani

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    ,
    Arash Letafati

    Department of Virology, School of public health, Tehran University of Medical Science, Tehran, Iran

    ,
    Alireza Khatami

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    ,
    Rana Farzi

    Department of Virology, Faculty of Medicine, Shiraz University of Medical Science, Shiraz, Iran

    ,
    Soha Shabani

    Faculty of veterinary medicine, Azad University, Research Sciences Branch, Tehran, Iran

    ,
    Pouya Moradi

    Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    ,
    Vahid Tambrchi

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    ,
    Hassan Saadati

    Department of Epidemiology & Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran

    ,
    Saher Papizadeh

    Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran

    ,
    Mona Vasei Rad

    Paramedicine Department, Islamic Azad University, Babol Medical Sciences Branch, Babol, Mazandaran, Iran

    ,
    Raheleh Tabatabaei

    Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    ,
    Saeed Bahadory

    Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    ,
    Ahmad Tavakoli

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    Research Center of Pediatric Infectious Diseases, Institute of Immunology & Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

    ,
    Farah Bokharaei-Salim

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    ,
    Seyed Hamidreza Monavari

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    ,
    Maryam Fatemipour

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    ,
    Mahdieh Hoseini

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    &
    Seyed Jalal Kiani

    *Author for correspondence: Tel.: +98 021 8860 2205;

    E-mail Address: kiani.j@iums.ac.ir

    Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran

    Published Online:https://doi.org/10.2217/fvl-2021-0096

    Aim: The present study aimed to find out the prevalence and any possible association between human herpesvirus (HHV-6) and primary brain tumors. Materials & methods: The systematic literature search was performed by finding related articles from major databases. Analysis was performed by comprehensive meta-analysis software. Results: A total of 13 (25 datasets) articles were included in the study, seven (15 datasets) of which were case/control and the rest (10 datasets) were cross-sectional studies. The pooled prevalence of HHV-6 among primary brain cancer patients was 29% (95% CI: 24–33%; I2 = 97.89%). An association was found between HHV-6 and primary brain cancer (summary odds ratio: 3.77% [95% CI: 2.59–5.49%; I2 = 19.0%]). Conclusion: Our analysis demonstrated that HHV-6 is associated with primary brain cancer. Reactivation of the virus could be triggered by the tumor, therefore, we cannot be certain that the virus appeared before the cancer development.

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