Effect of exogenous expression of IFN-γ on the new world alphavirus replication and infection

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1. Lin FC , Young HA . Interferons: success in anti-viral immunotherapy. Cytokine Growth Factor Rev. 25(4), 369–376 (2014).
  Medline CASGoogle Scholar
• 2. Schroder K , Hertzog PJ , Ravasi T , Hume DA . Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75(2), 163–189 (2004). • An overview covering the well-characterized responses of IFN-γ that alter macrophage function during infection.
  Medline CASGoogle Scholar
• 3. Peng T , Zhu J , Hwangbo Y , Corey L , Bumgarner RE . Independent and cooperative antiviral actions of beta interferon and gamma interferon against herpes simplex virus replication in primary human fibroblasts. J. Virol. 82(4), 1934–1945 (2008).
  Medline CASGoogle Scholar
• 4. Sainz B Jr , Halford WP . Alpha/beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1. J. Virol. 76(22), 11541–11550 (2002).
  Medline CASGoogle Scholar
• 5. Shakya AK , O’Callaghan DJ , Kim SK . Interferon gamma inhibits varicella-zoster virus replication in a cell line-dependent manner. J. Virol. 93(12), 1–16 (2019).
  Google Scholar
• 6. Frese M , Schwarzle V , Barth K et al. Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology 35(3), 694–703 (2002).
  Medline CASGoogle Scholar
• 7. Moraes MP , de Los Santos T , Koster M et al. Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type I and II porcine interferons. J. Virol. 81(13), 7124–7135 (2007).
  Medline CASGoogle Scholar
• 8. Obojes K , Andres O , Kim KS , Daubener W , Schneider-Schaulies J . Indoleamine 2,3-dioxygenase mediates cell type-specific anti-measles virus activity of gamma interferon. J. Virol. 79(12), 7768–7776 (2005).
  Medline CASGoogle Scholar
• 9. Lin YL , Huang YL , Ma SH et al. Inhibition of Japanese encephalitis virus infection by nitric oxide: antiviral effect of nitric oxide on RNA virus replication. J. Virol. 71(7), 5227–5235 (1997).
  Medline CASGoogle Scholar
• 10. Der SD , Zhou A , Williams BR , Silverman RH . Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc. Natl Acad. Sci. USA 95(26), 15623–15628 (1998).
  Medline CASGoogle Scholar
• 11. Karupiah G , Xie QW , Buller RM , Nathan C , Duarte C , MacMicking JD . Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 261(5127), 1445–1448 (1993). •• Demonstrated that the direct inhibition of viral replication by IFN-γ is through induction of nitric oxide synthase.
  Medline CASGoogle Scholar
• 12. Biron CA , Sen GC . Innate responses to viral infections. In: Fields Virology. Knipe DM Howley PM (Eds). Lippincott Williams & Wilkins, PA, USA, 249–278 (2007).
  Google Scholar
• 13. van Boxel-Dezaire AH , Stark GR . Cell type-specific signaling in response to interferon-gamma. Curr. Top. Microbiol. Immunol. 316, 119–154 (2007).
  Medline CASGoogle Scholar
• 14. Garmashova N , Gorchakov R , Volkova E , Paessler S , Frolova E , Frolov I . The old world and new world alphaviruses use different virus-specific proteins for induction of transcriptional shutoff. J. Virol. 81(5), 2472–2484 (2007).
  Medline CASGoogle Scholar
• 15. Griffin DE . Alphaviruses. In: Fields Virology. Knipe DM Howley PM (Eds). Lippincott Williams & Wilkins, PA, USA, 1023–1067 (2007).
  Google Scholar
• 16. Pratt WD , Hart MK , Reed DS , Steele KE . Alphaviruses. In: Biodefense: Research Methodology and Animal Models. Swearengen JR (Ed.). CRC Press, FL, USA, 181–206 (2006).
  Google Scholar
• 17. Weaver SC , Ferro C , Barrera R , Boshell J , Navarro JC . Venezuelan equine encephalitis. Annu. Rev. Entomol. 49, 141–174 (2004).
  Medline CASGoogle Scholar
• 18. Rivas F , Diaz LA , Cardenas VM et al. Epidemic Venezuelan equine encephalitis in La Guajira, Colombia. J. Infect. Dis. 175(4), 828–832 (1997).
  Medline CASGoogle Scholar
• 19. Binder GK , Griffin DE . Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528), 303–306 (2001). •• Showed first time that T cells used IFN-γ to clear the old world alphaviurs infection in the CNS.
  Medline CASGoogle Scholar
• 20. Burdeinick-Kerr R , Griffin DE . Gamma interferon-dependent, noncytolytic clearance of sindbis virus infection from neurons in vitro . J. Virol. 79(9), 5374–5385 (2005).
  Medline CASGoogle Scholar
• 21. Lee EY , Schultz KL , Griffin DE . Mice deficient in interferon-gamma or interferon-gamma receptor 1 have distinct inflammatory responses to acute viral encephalomyelitis. PLoS ONE 8(10), 1–13 (2013).
  Google Scholar
• 22. Burdeinick-Kerr R , Wind J , Griffin DE . Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J. Virol. 81(11), 5628–5636 (2007).
  Medline CASGoogle Scholar
• 23. Baxter VK , Griffin DE . Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis. J. Gen. Virol. 97(11), 2908–2925 (2016).
  Medline CASGoogle Scholar
• 24. Ryman KD , Meier KC , Gardner CL , Adegboyega PA , Klimstra WB . Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons. Virology 368(2), 273–285 (2007).
  Medline CASGoogle Scholar
• 25. Lee CS , Bishop ES , Zhang R et al. Adenovirus-mediated gene delivery: potential applications for gene and cell-based therapies in the new era of personalized medicine. Genes Dis. 4(2), 43–63 (2017).
  Medline CASGoogle Scholar
• 26. Nagata LP , Hu WG , Parker M et al. Infectivity variation and genetic diversity among strains of Western equine encephalitis virus. J. Gen. Virol. 87(Pt 8), 2353–2361 (2006).
  Medline CASGoogle Scholar
• 27. Wu JQ , Barabe ND , Chau D et al. Complete protection of mice against a lethal dose challenge of western equine encephalitis virus after immunization with an adenovirus-vectored vaccine. Vaccine 25(22), 4368–4375 (2007).
  Medline CASGoogle Scholar
• 28. He TC , Zhou S , da Costa LT , Yu J , Kinzler KW , Vogelstein B . A simplified system for generating recombinant adenoviruses. Proc. Natl Acad. Sci. USA 95(5), 2509–2514 (1998).
  Medline CASGoogle Scholar
• 29. Mahy BWJ , Kangro HO . Virology Methods Manual. Academic Press, CA, USA (1996).
  Google Scholar
• 30. Wu JQ , Barabe ND , Huang YM , Rayner GA , Christopher ME , Schmaltz FL . Pre- and post-exposure protection against western equine encephalitis virus after single inoculation with adenovirus vector expressing interferon alpha. Virology 369(1), 206–213 (2007). • Demonstrated that adenovirus-mediated IFN-γ gene therapy has a potential to be used as a single-dose regime to prevent the lethal infection of a new world alphavirus.
  Medline CASGoogle Scholar
• 31. Steele KE , Twenhafel NA . Review paper: pathology of animal models of alphavirus encephalitis. Vet. Pathol. 47(5), 790–805 (2010). •• A review paper to summarize the current animal models for the new world alphaviruses.
  Medline CASGoogle Scholar
• 32. Chesler DA , Reiss CS . The role of IFN-γamma in immune responses to viral infections of the central nervous system. Cytokine Growth Factor Rev. 13(6), 441–454 (2002). • A review on the mechanism of IFN-γ mediated antiviral effect on viral infections of the CNS.
  Medline CASGoogle Scholar
• 33. Komatsu T , Bi Z , Reiss CS . Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons. J. Neuroimmunol. 68(1–2), 101–108 (1996).
  Medline CASGoogle Scholar
• 34. Griffin DE . Immune responses to RNA-virus infections of the CNS. Nat. Rev. Immunol. 3(6), 493–502 (2003). • A detailed review on the roles of cytotoxic T cells, antibodies and cytokines in the clearance of viral infection from neurons, glial cells and meningeal cells.
  Medline CASGoogle Scholar
• 35. Grieder FB , Vogel SN . Role of interferon and interferon regulatory factors in early protection against Venezuelan equine encephalitis virus infection. Virology 257(1), 106–118 (1999).
  Medline CASGoogle Scholar
• 36. Schijns VE , Van der Neut R , Haagmans BL , Bar DR , Schellekens H , Horzinek MC . Tumour necrosis factor-alpha, interferon-gamma and interferon-beta exert antiviral activity in nervous tissue cells. J. Gen. Virol. 72(Pt 4), 809–815 (1991).
  Medline CASGoogle Scholar
• 37. Zhang Y , Burke CW , Ryman KD , Klimstra WB . Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J. Virol. 81(20), 11246–11255 (2007). • Demonstrated that several interferon-stimulated proteins are responsible for the antiviral effect of interferons against the alphaviruses.
  Medline CASGoogle Scholar
• 38. Aguilar PV , Adams AP , Wang E et al. Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence. J. Virol. 82(10), 4920–4930 (2008).
  Medline CASGoogle Scholar
• 39. Alevizatos AC , McKinney RW , Feigin RD . Live, attenuated Venezuelan equine encephalomyelitis virus vaccine. I. Clinical effects in man. Am. J. Trop. Med. Hyg. 16(6), 762–768 (1967).
  Medline CASGoogle Scholar
• 40. White LJ , Wang JG , Davis NL , Johnston RE . Role of alpha/beta interferon in Venezuelan equine encephalitis virus pathogenesis: effect of an attenuating mutation in the 5´ untranslated region. J. Virol. 75(8), 3706–3718 (2001).
  Medline CASGoogle Scholar
• 41. Kulasegaran-Shylini R , Thiviyanathan V , Gorenstein DG , Frolov I . The 5´UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins. Virology 387(1), 211–221 (2009).
  Medline CASGoogle Scholar
• 42. Mistchenko AS , Diez RA , Falcoff R . Recombinant human interferon-gamma inhibits adenovirus multiplication without modifying viral penetration. J. Gen. Virol. 68(Pt 10), 2675–2679 (1987).
  Medline CASGoogle Scholar
• 43. Mistchenko AS , Falcoff R . Recombinant human interferon-gamma inhibits adenovirus multiplication in vitro . J. Gen. Virol. 68(Pt 3), 941–944 (1987).
  Medline CASGoogle Scholar
• 44. Lemiale F , Kong WP , Akyurek LM et al. Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system. J. Virol. 77(18), 10078–10087 (2003).
  Medline CASGoogle Scholar
• 45. Toyobuku H , Sai Y , Kagami T , Tamai I , Tsuji A . Delivery of peptide drugs to the brain by adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood–brain barrier. J. Pharmacol. Exp. Ther. 305(1), 40–407 (2003).
  Medline CASGoogle Scholar
• 46. Tang Y , Han T , Everts M et al. Directing adenovirus across the blood–brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model. Gene Ther. 14(6), 523–532 (2007).
  Medline CASGoogle Scholar
• 47. Yin J , Gardner CL , Burke CW , Ryman KD , Klimstra WB . Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses. J. Virol. 83(19), 10036–10047 (2009).
  Medline CASGoogle Scholar