Why do young adults living with HIV perform poorly on combined antiretroviral therapy (CART)? – a Zimbabwean perspective

References

• 1 Judd A, Lodwick R, Noguera-Julian A et al. Higher rates of triple-class virological failure in perinatally HIV-infected teenagers compared with heterosexually infected young adults in Europe . HIV Med. 18(3), 171–180 (2017).
  Medline CASGoogle Scholar
• 2 Lee S, Hazra R. Achieving 90-90-90 in paediatric HIV: adolescence as the touchstone for transition success. J. Int. AIDS Soc. 18(Suppl. 6), 20257 (2015).
  MedlineGoogle Scholar
• 3 Machado DM, Succi RC, Turato ER. Transitioning adolescents living with HIV/AIDS to adult-oriented health care: an emerging challenge. J. Pediatr. 86(6), 465–472 (2010).
  Google Scholar
• 4 Vreeman RC, Scanlon ML, McHenry MS et al. The physical and psychological effects of HIV infection and its treatment on perinatally HIV-infected children. J. Int. AIDS Soc. 18(Suppl. 6), 20258 (2015).
  MedlineGoogle Scholar
• 5 Arrive E, Dicko F, Amghar H et al. HIV status disclosure and retention in care in HIV-infected adolescents on antiretroviral therapy (ART) in West Africa. PLoS ONE 7(3), e33690 (2012).
  Medline CASGoogle Scholar
• 6 Gamarel KE, Brown L, Kahler CW et al. Prevalence and correlates of substance use among youth living with HIV in clinical settings. Drug Alcohol Depend. 169, 11–18 (2016).
  MedlineGoogle Scholar
• 7 Maskew M, Fox MP, Evans D et al. Insights into adherence among a cohort of adolescents aged 12–20years in South Africa: reported barriers to antiretroviral treatment. AIDS Res. Treat. 2016, 1–12 (2016).
  Google Scholar
• 8 Willis N, Mavhu W, Wogrin C et al. Understanding the experience and manifestation of depression in adolescents living with HIV in Harare, Zimbabwe. PLoS ONE 13(1), e0190423 (2018).
  MedlineGoogle Scholar
• 9 Vreeman RC, McCoy BM, Lee S. Mental health challenges among adolescents living with HIV. J. Int. AIDS Soc. 20(Suppl. 3), 21497 (2017).
  MedlineGoogle Scholar
• 10 Lowenthal ED, Bakeera-Kitaka S, Marukutira T et al. Perinatally acquired HIV infection in adolescents from sub-Saharan Africa: a review of emerging challenges. Lancet Infect. Dis. 14(7), 627–639 (2014).
  MedlineGoogle Scholar
• 11 Laughton B, Cornell M, Boivin M et al. Neurodevelopment in perinatally HIV-infected children: a concern for adolescence. J. Int. AIDS Soc. 16, 18603 (2013).
  MedlineGoogle Scholar
• 12 Ayano G, Solomon M, Abraha M. A systematic review and meta-analysis of epidemiology of depression in people living with HIV in east Africa. BMC Psychiatry 18(1), 254 (2018).
  MedlineGoogle Scholar
• 13 Bigna JJ, Tounouga DN, Kenne AM et al. Epidemiology of depressive disorders in people living with HIV in Africa: a systematic review and meta-analysis: Burden of depression in HIV in Africa. Gen. Hosp. Psychiatry 57, 13–22 (2018).
  MedlineGoogle Scholar
• 14 Barroso J, Burrage J, Carlson J et al. Salivary cortisol values in HIV-positive people. J. Assoc. Nurses AIDS Care 17(3), 29–36 (2006).
  MedlineGoogle Scholar
• 15 Richter L, Makusha T, Komarek A et al. Exploring the impact of childhood abuse on HIV social and attitudinal factors among adults with and without this history in sub-saharan africa: findings from NIMH project accept (HPTN 043). AIDS Behav. 20(4), 737–745 (2016).
  MedlineGoogle Scholar
• 16 Rowe C, Santos GM, McFarland W et al. Prevalence and correlates of substance use among trans female youth ages 16–24 years in the San Francisco Bay Area. Drug Alcohol Depend. 147, 160–166 (2015).
  MedlineGoogle Scholar
• 17 Ahmed-Leitao F, Spies G, van den Heuvel L et al. Hippocampal and amygdala volumes in adults with posttraumatic stress disorder secondary to childhood abuse or maltreatment: a systematic review. Psychiatry Res. Neuroimaging 256, 33–43 (2016).
  MedlineGoogle Scholar
• 18 Zimbabwe Church, Health Ministry Launches Anti-Drug Campaign (2019). www.voanews.com/a/zimbabwe-youth-substance-abuse/4735119.html. •Alcohol and substance use is a rising problem in all of Africa, and also in Zimbabwe, and it has become one of our top three diagnoses.
  Google Scholar
• 19 Georgsson G. Neuropathologic aspects of lentiviral infections. Ann. NY Acad. Sci. 724, 50–67 (1994).
  Medline CASGoogle Scholar
• 20 Persidsky Y, Poluektova L. Immune privilege and HIV-1 persistence in the CNS. Immunol. Rev. 213, 180–194 (2006).
  Medline CASGoogle Scholar
• 21 Hazleton JE, Berman JW, Eugenin EA. Novel mechanisms of central nervous system damage in HIV infection. HIV AIDS 2, 39–49 (2010).
  CASGoogle Scholar
• 22 Williams DW, Veenstra M, Gaskill PJ et al. Monocytes mediate HIV neuropathogenesis: mechanisms that contribute to HIV associated neurocognitive disorders. Curr. HIV Res. 12(2), 85–96 (2014).
  Medline CASGoogle Scholar
• 23 Lamers SL, Fogel GB, Nolan DJ et al. HIV-associated neuropathogenesis: a systems biology perspective for modeling and therapy. Biosystems 119, 53–61 (2014).
  MedlineGoogle Scholar
• 24 Brack-Werner R, Bell JE. Replication of HIV-1 in human astrocytes. NeuroAids 2(8), 1–22 (1999).
  MedlineGoogle Scholar
• 25 Li GH, Henderson L, Nath A. Astrocytes as an HIV reservoir: mechanism of HIV infection. Curr. HIV Res. 14(5), 373–381 (2016).
  Medline CASGoogle Scholar
• 26 Eugenin EA, Clements JE, Zink MC et al. Human immunodeficiency virus infection of human astrocytes disrupts blood–brain barrier integrity by a gap junction-dependent mechanism. J. Neurosci. 31(26), 9456–9465 (2011).
  Medline CASGoogle Scholar
• 27 Yu F, Hao Y, Zhao H et al. Distinct mitochondrial disturbance in CD4+T and CD8+T cells from hiv-infected patients. J. Acquir. Immune Defic. Syndr. 74(2), 206–212 (2017).
  Medline CASGoogle Scholar
• 28 Saylor D, Dickens AM, Sacktor N et al. HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment. Nat. Rev. Neurol. 12(5), 309 (2016).
  MedlineGoogle Scholar
• 29 Joska JA, Fincham DS, Stein DJ et al. Clinical correlates of HIV-associated neurocognitive disorders in South Africa. AIDS Behav. 14(2), 371–378 (2010).
  MedlineGoogle Scholar
• 30 Ortega M, Heaps JM, Joska J et al. HIV clades B and C are associated with reduced brain volumetrics. J. Neurovirol. 19(5), 479–487 (2013).
  MedlineGoogle Scholar
• 31 UNAIDS ‘AIDSinfo’ (2019). www.unaids.org/en/resources/fact-sheet.
  Google Scholar