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Peripheral follicular helper T cells in acute viral diseases: a perspective on dengue

    Luis A Sánchez-Vargas

    Department of Cell & Molecular Biology, Institute for Immunology & Informatics, University of Rhode Island, Providence, RI 02903, USA

    &
    Anuja Mathew

    *Author for correspondence: Tel.: +1 401 277 5309; Fax: +1 401 277 5154;

    E-mail Address: mathewa@uri.edu

    Department of Cell & Molecular Biology, Institute for Immunology & Informatics, University of Rhode Island, Providence, RI 02903, USA

    Published Online:https://doi.org/10.2217/fvl-2018-0197

    Follicular helper T cells (TFH) are a predominant subset of CD4+ T cells specialized in providing help to B cells in germinal centers and necessary to generate T cell-dependent antibody responses. Peripheral TFH (pTFH) are the counterpart of TFH found in the circulation, which resemble TFH in many aspects of their phenotype and function. The CD4+ pTFH subset has received a lot of interest recently because they are easy to access and have the potential to serve as a biomarker for long-lasting humoral immunity. This review will discuss recent findings of pTFH in human acute viral diseases with a focus on dengue infection.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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