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Short Communication

A prospective study of enterovirus D68 in a regional UK center

    Published Online:5 Aug 2016https://doi.org/10.2217/fvl-2016-0036

    Abstract

    Aim: A prospective study was undertaken to establish the prevalence of enterovirus D68 (EV-D68) in the northwest of England. Patients & samples: In the period 24 October through 31 December 2014, respiratory samples were screened by a specific real-time PCR and EV-D68 was identified by nucleotide sequence-based typing. Results: Enterovirus was detected in 7.4% of samples and EV-D68 was confirmed in 32 cases. Phylogenetic analysis showed that EV-D68 strains corresponded to clades A and B. Clinical presentation of cases ranged from mild to severe respiratory infection. The majority of cases had comorbidities that might predispose to severe infection. Conclusion: EV-D68 was circulating in our region during late 2014 and has the potential to cause severe disease.

    References

    • 1 Romero J, Modlin J. Introduction to the human enteroviruses and parechoviruses. In: Principles and Practice of Infectious Diseases. Mandell GL, Bennett JE, Dolin R (Eds). Elsevier, Amsterdam, The Netherlands, 2066 (2015).
      Google Scholar
    • 2 Schieble JH, Fox VL, Lennette EH. A probable new human picornavirus associated with respiratory diseases. Am. J. Epidemiol. 85(2), 297–310 (1967).
      Medline CASGoogle Scholar
    • 3 Holm-Hansen CC, Midgley SE, Fischer TK. Global emergence of enterovirus D68: a systematic review. Lancet Infect. Dis. 16(5), e64–e75 (2016).
      MedlineGoogle Scholar
    • 4 CDC. Severe respiratory illness associated with enterovirus D68. MMWR Morb. Mortal. Wkly Rep. 63(36), 798–799 (2014).
      MedlineGoogle Scholar
    • 5 Poelman R, Schuffenecker I, Van Leer-Buter C, Josset L, Niesters HGM, Lina B. European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014. J. Clin. Virol. 71, 1–9 (2015).
      MedlineGoogle Scholar
    • 6 Poelman R, Schölvinck EH, Borger R, Niesters HGM, van Leer-Buter C. The emergence of enterovirus D68 in a Dutch university medical center and the necessity for routinely screening for respiratory viruses. J. Clin. Virol. 62, 1–5 (2015).
      MedlineGoogle Scholar
    • 7 Tokarz R, Firth C, Madhi SA et al. Worldwide emergence of multiple clades of enterovirus 68. J. Gen. Virol. 93(Pt 9), 1952–1958 (2012).
      Medline CASGoogle Scholar
    • 8 Bragstad K, Jakobsen K, Rojahn AE et al. High frequency of enterovirus D68 in children hospitalised with respiratory illness in Norway, autumn 2014. Influenza Other Respir. Viruses 9(2), 59–63 (2015).
      MedlineGoogle Scholar
    • 9 Imamura T, Fuji N, Suzuki A et al. Enterovirus 68 among children with severe acute respiratory infection, The Philippines. Emerg. Infect. Dis. 17(8), 1430–1435 (2011).
      MedlineGoogle Scholar
    • 10 Linsuwanon P, Puenpa J, Suwannakarn K et al. Molecular epidemiology and evolution of human enterovirus serotype 68 in Thailand, 2006–2011. PLoS ONE 7(5), e35190 (2012).
      Medline CASGoogle Scholar
    • 11 Liu Y, Sheng J, Fokine A et al. Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science 347(6217), 71–74 (2015).
      Medline CASGoogle Scholar
    • 12 Sun L, Meijer A, Froeyen M et al. Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68. Antimicrob. Agents Chemother. 59(12), 7782–7785 (2015).
      Medline CASGoogle Scholar
    • 13 Davison KL. The epidemiology of acute meningitis in children in England and Wales. Arch. Dis. Child. 88(8), 662–664 (2003).
      Medline CASGoogle Scholar
    • 14 Lauinger IL, Bible JM, Halligan EP, Aarons EJ, MacMahon E, Tong CYW. Lineages sub-lineages and variants of enterovirus 68 in recent outbreaks. PLoS ONE 7(4), e36005 (2012).
      Medline CASGoogle Scholar
    • 15 CDC. Clusters of acute respiratory illness associated with human enterovirus 68 – Asia, Europe, and United States. MMWR Morb. Mortal. Wkly Rep. 60(38), 1301–1304 (2011).
      MedlineGoogle Scholar
    • 16 Meijer A, van der Sanden S, Snijders BEP et al. Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010. Virology 423(1), 49–57 (2012).
      Medline CASGoogle Scholar
    • 17 Leshem E. Notes from the field: acute flaccid myelitis among persons aged ≤21 years – United States, August 1–November 13, 2014. MMWR Morb. Mortal. Wkly Rep. 63(53), 1243–1244 (2015).
      MedlineGoogle Scholar
    • 18 Kreuter JD, Barnes A, McCarthy JE et al. A fatal central nervous system enterovirus 68 infection. Arch. Pathol. Lab. Med. 135(6), 793–796 (2011).
      MedlineGoogle Scholar
    • 19 Oberste MS, Maher K, Schnurr D et al. Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses. J. Gen. Virol. 85(Pt 9), 2577–2584 (2004).
      Medline CASGoogle Scholar
    • 20 Baggen J, Thibaut HJ, Staring J et al. Enterovirus D68 receptor requirements unveiled by haploid genetics. Proc. Natl Acad. Sci. USA 113(5), 1399–1404 (2016).
      Medline CASGoogle Scholar