Cosmic radiation and cancer: is there a link?

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1 WHO. Ionizing Radiation. Cosmic Radiation. www.who.int
  Google Scholar
• 2 Sievert. www.sievert-system.org
  Google Scholar
• 3 Cosmic Rays. ec.europa.eu
  Google Scholar
• 4 Recommendations of the International Commission on Radiological Protection (ICRP). www.icrp.org
  Google Scholar
• 5 Australian Government. Australian Radiation Protection and Nuclear Safety Agency. www.arpansa.gov.au
  Google Scholar
• 6 Kim JN, Lee BM. Risk factors, health risks, and risk management for aircraft personnel and frequent flyers. J. Toxicol. Environ. Health B Crit. Rev. 10, 223–234 (2007).
  Medline CASGoogle Scholar
• 7 Friedberg W, Copeland K, Duke FE, Nicholas JS, Darden EB Jr, O'Brien K 3rd. Radiation exposure of aircrews. Occup. Med. 17, 293–309 (2002).
  MedlineGoogle Scholar
• 8 O'Brien K, Friedberg W, Duke FE et al. The exposure of aircraft crew to radiation of extra-terrestrial origin. Radiat. Protect. Dosim. 45, 145–162 (1992).
  Google Scholar
• 9 Obe G, Johannes I, Johannes C, Hallman K, Reitz G, Facius R. Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int. J. Radiat. Biol. 72, 727–734 (1997).
  Medline CASGoogle Scholar
• 10 Testard I, Ricoul M, Hoffschir F et al. Radiation-induced chromosome damage in astronauts’ lymphocytes. Int. J. Radiat. Biol. 70, 403–411 (1996).
  Medline CASGoogle Scholar
• 11 Yang TC, George K, Johnson AS, Durante M, Fedorenko BS. Biodosimetry results from space flight Mir-18. Radiat. Res. 148, 17–23 (1997).
  Google Scholar
• 12 Wolf G, Obe G, Bergau L. Cytogenetic investigations in flight personnel. Radiat. Protect. Dosim. 86, 275–278 (1999).
  Medline CASGoogle Scholar
• 13 Wolf G, Pieper R, Obe G. Chromosomal alterations in peripheral lymphocytes of female cabin attendants. Int. J. Radiat. Biol. 75, 829–836 (1999).
  Medline CASGoogle Scholar
• 14 Heimers A, Schröder H, Lengfelder E, Schmitz-Feuerhake I. Chromosome aberration analysis in aircrew members. Radiat. Protect. Dosim. 60, 171–175 (1995).
  Google Scholar
• 15 Heimers A. Chromosome aberration analysis in Concorde pilots. Mutat. Res. 467, 169–176. (2000).
  Medline CASGoogle Scholar
• 16 Cavallo D, Marinaccio A, Perniconi B et al. Chromosomal aberrations in long-haul air crew members. Mutat. Res. 513(1–2), 11–15 (2002).
  Medline CASGoogle Scholar
• 17 Fedorenko B. Cytogenic studies of blood lymphocytes from cosmonauts after long-term space flights on Mir station. Adv. Space Res. 27, 355–359 (2001).
  Medline CASGoogle Scholar
• 18 Greco O, Durante M, Gialanella G et al. Biological dosimetry in Russian and Italian astronauts. Adv. Space Res. 31, 1495–1503 (2003).
  Medline CASGoogle Scholar
• 19 Horstmann M, Durante M, Johannes C, Pieper R, Obe G. Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts lymphocytes. Radiat. Environ. Biophys. 44, 219–224 (2005).
  Medline CASGoogle Scholar
• 20 Fedorenko BS, Snigireva GP, Bogomazova AN, Novitskaia NN, Shevchenko VA. Cytogenetic effects on blood lymphocytes of cosmonauts after low doses of space. Radiat. Aviakosm Ekolog Med. 42, 13–18 (2008).
  Medline CASGoogle Scholar
• 21 Yong LC, Sigurdsin AJ, Ward EM et al. Increases frequency of chromosome translocations in airline pilots with long-term flying experience. Occup. Environ. Med. 66, 56–62 (2009).
  Medline CASGoogle Scholar
• 22 George K, Chappell LJ, Cucinotta FA. Persistence of space radiation induced cytogenetic damage in the blood lymphocytes of astronauts. Mutat. Res. 701(1), 75–79 (2010).
  Medline CASGoogle Scholar
• 23 George K, Rhone J, Beitman A, Cucinotta FA. Cytogenetic damage in the blood lymphocytes of astronauts: effects of repeat long-duration space missions. Mutat. Res. 756, 165–169 (2013).
  Medline CASGoogle Scholar
• 24 Salisbury DA, Band PR, Threlfall WJ, Gallagher RP. Mortality among British Columbia pilots. Aviat. Space Environ. Med. 62(4), 351–352 (1991).
  Medline CASGoogle Scholar
• 25 Irvine D, Davies DM. The mortality of British Airways pilots, 1966–1989: a proportional mortality study. Aviat. Space Environ. Med. 63(4), 276–279 (1992).
  Medline CASGoogle Scholar
• 26 Reynolds P, Cone J, Layefsky M, Goldberg DE, Hurley S. Cancer incidence in California flight attendants (United States). Cancer Causes Control 13, 317–324 (2002).
  MedlineGoogle Scholar
• 27 Dos Santos Silva I, De Stavola B, Pizzi C, Evans AD, Evans SA. Cancer incidence in professional flight crew and air traffic control officers: disentangling the effect of occupational versus lifestyle exposures. Int. J. Cancer 132, 374–384 (2013).
  Medline CASGoogle Scholar
• 28 Pukkala E, Auvinen A, Wahlberg G. Incidence of cancer among Finnish airline cabin attendants, 1967–92. BMJ 311(7006), 649–652 (1995).
  Medline CASGoogle Scholar
• 29 Linnersjö A, Hammar N, Dammström BG, Johansson M, Eliasch H. Cancer incidence in airline cabin crew: experience from Sweden. Occup. Environ. Med. 60, 810–814 (2003).
  Medline CASGoogle Scholar
• 30 Rafnsson V, Tulinius H, Jónasson JG, Hrafnkelsson J. Risk of breast cancer in female flight attendants: a population based study (Iceland). Cancer Causes Control 12, 95–101 (2001).
  Medline CASGoogle Scholar
• 31 Rafnsson V, Hrafnkelsson J, Tulinius H. Incidence of cancer among commercial airline pilots. Occup. Environ. Med. 57, 175–179 (2000).
  Medline CASGoogle Scholar
• 32 Haldorsen T, Reitan JB, Tveten U. Cancer incidence among Norwegian airline cabin attendants. Int. J. Epidemiol. 30, 825–830 (2001).
  Medline CASGoogle Scholar
• 33 Pukkala E, Aspholm R, Auvinen A et al. Incidence of cancer among Nordic airline pilots over five decades: occupational cohort study. BMJ 325, 567 (2002).
  MedlineGoogle Scholar
• 34 Boice J. Ionizing radiation. In: Cancer Epidemiology and Prevention (3rd Edition). Schottenfeld D, Fraumeni JF Jr (Eds). Oxford University Press, NY, USA, 259–293 (2006).
  Google Scholar
• 35 Gundestrup M, Storm HH. Radiation-induced acute myeloid leukaemia and other cancers in commercial jet cockpit crew: a population-based cohort study. Lancet 354, 2029–2031 (1999)•• Both malignant melanoma and skin cancer were found in excess in cockpit crew members with a long flying history, probably attributable to sun exposure during leisure time at holiday destinations. The study shows that male cockpit crew members have significantly increased frequency of acute myeloid leukemia.
  Medline CASGoogle Scholar
• 36 Pukkala E, Helminen M, Haldorsen T et al. Cancer incidence among Nordic airline cabin crew. Int. J. Cancer 131, 2886–2897 (2012).
  Medline CASGoogle Scholar
• 37 Zeeb H, Blettner M, Langner I et al. Mortality from cancer and other causes among airline cabin attendants in Europe: a collaborative cohort study in eight countries. Am. J. Epidemiol. 158, 35–46 (2003).
  MedlineGoogle Scholar
• 38 Blettner M, Zeeb H, Auvinen A et al. Mortality from cancer and other causes among male airline cockpit crew in Europe. Int. J. Cancer 106, 946–952 (2003).• In a separate analysis of 28,000 male airline cockpit crew, overall cancer mortality was decreased while mortality from malignant melanoma was increased.
  Medline CASGoogle Scholar
• 39 Langner I, Blettner M, Gundestrup M et al. Cosmic radiation and cancer mortality among airline pilots: results from a European cohort study (ESCAPE). Radiat. Environ. Biophys. 42, 247–256. (2004).
  Medline CASGoogle Scholar
• 40 Hammer GP, Auvinen A, De Stavola BL et al. Mortality from cancer and other causes in commercial airline crews: a joint analysis of cohorts from 10 countries. Occup. Environ. Med. 71, 313–322 (2014).• This study conducted on 93,771 crew members from ten countries followed for a mean of 21.7 years, showed that mortality from female breast cancer, leukemia and brain cancer was similar to that of the general population while mortality from malignant melanoma was elevated also in male cockpit crew.
  MedlineGoogle Scholar
• 41 Ballard TJ, Lagorio S, De Santis M et al. A retrospective cohort mortality study of Italian commercial airline cockpit crew and cabin attendants, 1965–1996. Int. J. Occup. Environ. Health 8, 87–96 (2002).
  MedlineGoogle Scholar
• 42 Paridou A, Velonakis E, Langner I, Zeeb H, Blettner M, Tzonou A. Mortality among pilots and cabin crew in Greece, 1960–1997. Int. J. Epidemiol. 32, 244–247 (2003).
  Medline CASGoogle Scholar
• 43 Blettner M, Zeeb H, Langner I, Hammer GP, Schafft T. Mortality from cancer and other causes among airline cabin attendants in Germany, 1960–1997. Am. J. Epidemiol. 156, 556–565 (2002).
  MedlineGoogle Scholar
• 44 Hammer GP, Blettner M, Langner I, Zeeb H. Cosmic radiation and mortality from cancer among male German airline pilots: extended cohort follow-up. Eur. J. Epidemiol. 27, 419–429 (2012).
  MedlineGoogle Scholar
• 45 Zeeb H, Hammer GP, Langner I, Schafft T, Bennack S, Blettner M. Cancer mortality among German aircrew: second follow-up. Radiat. Environ. Biophys. 49, 187–194 (2010).
  MedlineGoogle Scholar
• 46 Pinkerton LE, Waters MA, Hein MJ, Zivkovich Z, Schubauer-Berigan MK, Grajewski B. Cause-specific mortality among a cohort of US flight attendants. Am. J. Industrial Med. 55, 25–36. (2012).
  MedlineGoogle Scholar
• 47 Yong LC, Pinkerton LE, Yiin JH, Anderson JL, Deddens JA. Mortality among a cohort of US commercial airline cockpit crew. Am. J. Industrial Med. 57(8), 906–914 (2014).
  MedlineGoogle Scholar
• 48 Ballard T, Lagorio S, De Angelis G, Verdecchia A. Cancer incidence and mortality among flight personnel: a metaanalysis. Aviat. Space Environ. Med. 71, 216–224 (2000).• This study showed an excess of cancer risk for carcinoma of the colon, prostate, brain and melanoma among men flight crew and an increased risk for breast cancer, colon cancer and melanoma in women.
  Medline CASGoogle Scholar
• 49 Buja A, Lange JH, Perissinotto E et al. Cancer incidence among male military and civil pilots and flight attendants: an analysis on published data. Toxicol. Ind. Health 21, 273–282 (2005).•• This meta-analysis showed an increase of risk for melanoma and other nonmelanoma skin cancers in flight attendants, civilian pilots and military pilots. An increased risk for prostate cancer in civilian pilots also is reported.
  MedlineGoogle Scholar
• 50 Buja A, Mastrangelo G, Perissinotto E et al. Cancer incidence among female flight attendants: a meta-analysis of published data. J. Womens Health (Larchmt) 15, 98–105 (2006).•• This meta-analysis showed a significant excess of melanoma and breast carcinoma in female flight attendants.
  MedlineGoogle Scholar
• 51 Tokumaru O, Haruki K, Bacal K, Katagiri T, Yamamoto T, Sakurai Y. Incidence of cancer among female flight attendants: a meta-analysis. J. Travel Med. 13, 127–132 (2006).•• This meta-analysis showed a statistically significant increase in risk for breast cancer and for melanoma in female flight attendants.
  MedlineGoogle Scholar
• 52 Pizzi C, Evans SA, De Stavola BL, Evans A, Clemens F, Silva Idos S. Lifestyle of UK commercial aircrews relative to air traffic controllers and the general population. Aviat. Space Environ. Med. 79, 964–974 (2008).
  MedlineGoogle Scholar
• 53 Kojo K, Pukkala E, Auvinen A. Breast cancer risk among Finnish cabin attendants: a nested case–control study. Occup. Environ. Med. 62, 488–493 (2005).
  Medline CASGoogle Scholar
• 54 Schubauer-Berigan M, Hein M, Anderson J et al. Breast cancer incidence among flight attendants. Occup. Environ. Med. 71(Suppl. 1), A46 (2014).
  Google Scholar
• 55 Winter M, Blettner M, Zeeb H. Prevalence of risk factors for breast cancer in German airline cabin crew: a cross-sectional study. J. Occup. Med. Toxicol. 9, 27 (2014).
  MedlineGoogle Scholar
• 56 Kojo K, Helminen M, Pukkala E, Auvinen A. Risk factors for skin cancer among Finnish airline cabin crew. Ann. Occup. Hygiene 57, 695–704 (2013).
  Medline CASGoogle Scholar
• 57 Youk AO, Buchanich JM, Fryzek J, Cunningham M, Marsh GM. An ecological study of cancer mortality rates in high altitude counties of the United States. High Alt. Med. Biol. 13, 98–104. (2012).
  MedlineGoogle Scholar