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Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer

    Camille C Gunderson

    University of Oklahoma Health Sciences Center, Stephenson Oklahoma Cancer Center, 800 NE 10th Street, Suite 5040, Oklahoma City, OK 73104, USA

    &
    Kathleen N Moore

    *Author for correspondence:

    E-mail Address: kathleen-moore@ouhsc.edu

    University of Oklahoma Health Sciences Center, Stephenson Oklahoma Cancer Center, 800 NE 10th Street, Suite 5040, Oklahoma City, OK 73104, USA

    Published Online:https://doi.org/10.2217/fon.14.313

    ABSTRACT 

    Olaparib (Lynparza™; AZD2281) is a potent PARP-1 and PARP-2 inhibitor with biologic activity in ovarian cancer as well as other solid tumors. It has been tested in Phase I and II trials and has single-agent activity in both germline BRCA mutated and sporadic ovarian cancer. Phase III trials assessing the efficacy of olaparib in the maintenance setting following first line and platinum-sensitive recurrence are underway for patients with a germline BRCA mutation, given the inherent molecular compatibility with the drug's mechanism of action.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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