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Supplement

Cytoreductive surgery and hyperthermic intrapleural chemotherapy for malignant pleural diseases: preliminary experience

    Marcello Migliore

    *Author for correspondence:

    E-mail Address: mmiglior@unict.it

    Academic Thoracic Surgery Unit, A.O.U. Policlinico-Vittorio Emanuele, Department of Surgery, University of Catania, Catania, Italy

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    ,
    Damiano Calvo

    Academic Thoracic Surgery Unit, A.O.U. Policlinico-Vittorio Emanuele, Department of Surgery, University of Catania, Catania, Italy

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    ,
    Alessandra Criscione

    Academic Thoracic Surgery Unit, A.O.U. Policlinico-Vittorio Emanuele, Department of Surgery, University of Catania, Catania, Italy

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    ,
    Cristina Viola

    Academic Thoracic Surgery Unit, A.O.U. Policlinico-Vittorio Emanuele, Department of Surgery, University of Catania, Catania, Italy

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    ,
    Giuseppe Privitera

    Radiotherapy Unit, A.O.U. Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy

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    ,
    Corrado Spatola

    Radiotherapy Unit, A.O.U. Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy

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    ,
    Hector Soto Parra

    Oncology Unit, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy

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    ,
    Stefano Palmucci

    Radiology Unit, A.O.U. Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy

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    ,
    Nicola Ciancio

    Pneumology Unit, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy

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    ,
    Rosario Caltabiano

    Department of Pathology, University of Catania, Catania, Italy

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    &
    Giuseppe Di Maria

    Pneumology Unit, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy

    Department of Clinical & Molecular Bio-Medicine, University of Catania, Catania, Italy

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    Published Online:9 Feb 2015https://doi.org/10.2217/fon.14.256

    Abstract

    ABSTRACT 

    Cytoreductive surgery and hyperthermic-intraoperative-intrapleural-chemotherapy (HITHOC) is a known approach for malignant pleural diseases (MPD). This study was started to clarify the role of cytoreductive surgery and HITHOC in MPD. Criteria of inclusion were early-stage disease in malignant pleural mesothelioma (MPM), young age, good condition and selected stage-M1a lung cancer. Six patients with MPM and two patients with lung cancer were enrolled. After surgical debulking, intrapleural cisplatin was administered for 60 min at 42.5°C. Wedge, rib resection and repaired diaphragm were added in three, one and one patient, respectively. Morbidity, toxicity and mortality was nil. Hospital stay was 8 days. Mean survival is 13.6 months. This experience confirms that cytoreductive surgery and HITHOC is a good option in the treatment of MPD. A randomized controlled trial is necessary.

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