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Serum sarcosine is a risk factor for progression and survival in patients with metastatic castration-resistant prostate cancer

    Giuseppe Lucarelli

    * Author for correspondence

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy. .

    ,
    Pasquale Ditonno

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    Authors contributed equally

    Search for more papers by this author

    ,
    Carlo Bettocchi

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    ,
    Marco Spilotros

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    ,
    Monica Rutigliano

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    ,
    Antonio Vavallo

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    ,
    Vanessa Galleggiante

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    ,
    Margherita Fanelli

    Department of Biomedical Sciences, Section of Hygiene, University of Bari, Bari, Italy

    ,
    Angela Maria Vittoria Larocca

    Department of Internal Medicine & Public Medicine, Section of Medical Statistics, University of Bari, Bari, Italy

    ,
    Cinzia Annatea Germinario

    Department of Internal Medicine & Public Medicine, Section of Medical Statistics, University of Bari, Bari, Italy

    ,
    Eugenio Maiorano

    Department of Pathological Anatomy, University of Bari, Bari, Italy

    ,
    Francesco Paolo Selvaggi

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    &
    Michele Battaglia

    Department of Emergency & Organ Transplantation, Urology, Andrology & Kidney Transplantation Unit Piazza Giulio Cesare 11, 70124 Bari, Italy

    Published Online:https://doi.org/10.2217/fon.13.50

    Aim: Sarcosine has been identified as a differential metabolite that is greatly increased during progression from normal tissue to prostate cancer and metastatic disease. In this study we assessed the role of serum sarcosine in metastatic castration-resistant prostate cancer (mCRPC) patients. Patients & methods: Data from 52 mCRPC patients treated with docetaxel-based chemotherapy were retrospectively analyzed. Receiver operating characteristic curves, and Kaplan–Meier and Cox multivariate analyses were performed. Results: Median sarcosine values were significantly higher in mCRPC versus non-mCRPC patients (0.81 vs 0.52 nmol/µl; p < 0.0001). A significant correlation resulted between serum sarcosine levels and the duration of hormone sensitivity (Spearman’s correlation coefficient: -0.51; p = 0.001). At multivariate analysis sarcosine was an independent prognostic factor of outcome in terms of overall and progression-free survival. Conclusion: Serum sarcosine values were significantly increased in patients with metastatic disease. Moreover, this biomarker is a risk factor for progression and survival in chemotherapy-treated mCRPC patients.

    Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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