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Clinical significance of baseline Epstein–Barr virus DNA for recurrent or metastatic primary pulmonary lymphoepithelioma-like carcinoma

    Qihua Zou‡

    Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

    State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

    ‡Authors contributed equally

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    ,
    Kongjia Luo‡

    State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

    Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China

    ‡Authors contributed equally

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    ,
    Liping Kang‡

    Department of Medical Oncology, Yuebei People's Hospital, Shaoguan, China

    ‡Authors contributed equally

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    ,
    Caiwen Huang

    Department of Medical Oncology, Cancer Hospital Chinese Academy of Medical Sciences Shenzhen Center, Shenzhen, China

    Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Shenzhen, China

    ,
    Jianliang Mai

    Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

    State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

    ,
    Yongbin Lin

    **Author for correspondence: Tel.: +86 020 873 433 905;

    E-mail Address: linyb@sysucc.org.cn

    State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

    Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China

    &
    Ying Liang

    *Author for correspondence: Tel.: +86 020 873 433 68;

    E-mail Address: liangying@sysucc.org.cn

    Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China

    State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

    Published Online:https://doi.org/10.2217/fon-2023-0722

    Background: This study aimed to evaluate the clinical significance of baseline Epstein–Barr virus (EBV) DNA in recurrent or metastatic primary pulmonary lymphoepithelioma-like carcinoma (PLELC). Methods: 75 patients with baseline EBV DNA were included. The relationships between baseline EBV DNA and clinical characteristics, survival and objective response rate were analyzed. Results: The baseline EBV DNA levels were related to the liver, chest wall, distant lymph node(s) or multiple sites of distant metastasis. The high baseline EBV DNA group (≥41,900 copies/ml) was related to shorter progression-free and overall survival in univariate analysis and remained significant for progression-free survival in multivariate analysis. Conclusion: The baseline EBV DNA is a valuable biomarker for predicting prognosis and reflecting tumor burden in recurrent or metastatic PLELC.

    Tweetable abstract

    In this study, the baseline plasma EBV DNA level was related to tumor burden, and it was an independent prognostic indicator for PFS in recurrent or metastatic primary pulmonary lymphoepithelioma-like carcinoma.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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