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Meta-analysis of quality of life in patients with cancer treated with antibody-drug conjugates in randomized controlled trials

    Tianlei Qiu‡

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Guoshuang Shen‡

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Yuanfang Xin

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Jinming Li

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Yonghui Zheng

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Zijun Zhu

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Chengrong Zhang

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Yuyao Tang

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Miaozhou Wang

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Zhen Liu

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Yi Zhao

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Fuxing Zhao

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Dengfeng Ren

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    ,
    Huihui Li

    Department of Breast Medical Oncology, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China

    ,
    Yaobang Liu

    Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750000, China

    ,
    Xinlan Liu

    *Author for correspondence: Tel.: +86 137 095 773 39;

    E-mail Address: nxliuxinlan@163.com

    Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 750000, China

    &
    Jiuda Zhao

    **Author for correspondence: Tel.: +86 133 276 619 76;

    E-mail Address: jiudazhao@126.com

    Breast Disease Diagnosis & Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China.

    Published Online:https://doi.org/10.2217/fon-2023-0253

    Purpose: To evaluate the patient-reported outcomes of patients treated with commercially approved antibody-drug conjugates (ADC) reported in randomized controlled trials (RCT) published up to September 2023. Methods: A meta-analysis of 6430 patients from 12 randomized controlled trials was conducted. Results: No significant change was observed between the groups from baseline to end of treatment and end of follow-up, with a standardized mean difference of -0.08 (95% CI: -0.27–0.12) and 0.01 (95% CI: -0.11–0.12), respectively. Treatment with ADCs delayed the deterioration of patients' clinical condition compared with treatment with non-ADCs, with a hazard ratio of 0.78 (95% CI: 0.67–0.92). Conclusion: ADCs have a good correlation with delay of clinical deterioration in patients with cancer.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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