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Sex bias phenomenon in oral cancer: an insight

    Namrata Sengupta

    *Author for correspondence: Tel.: +91 811 680 7494;

    E-mail Address: dr.namrata.sengupta@gmail.com

    Department of Oral Pathology & Microbiology, Dr. D. Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, Maharashtra, 411018, India

    ,
    Sachin C Sarode

    Department of Oral Pathology & Microbiology, Dr. D. Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, Maharashtra, 411018, India

    ,
    Gargi S Sarode

    Department of Oral Pathology & Microbiology, Dr. D. Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, Maharashtra, 411018, India

    &
    Rahul Anand

    Department of Oral Pathology & Microbiology, Dr. D. Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, Maharashtra, 411018, India

    Published Online:https://doi.org/10.2217/fon-2023-0225
    Free first page

    Papers of special note have been highlighted as: • of interest

    References

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    • 2. Huang Q, Sun Y, Ma X et al. Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma. Nat. Commun. 8(1), 918 (2017).
    • 3. Bilski K, Zapała Ł, Skrzypczyk MA et al. Review on gender differences in non-muscle invasive bladder cancer. Transl. Androl. Urol. 8(1), 12–20 (2019).
    • 4. Fresno Vara JA, Casado E, de Castro J et al. PI3K/Akt signalling pathway and cancer. Cancer Treat. Rev. 30(2), 193–204 (2004).
    • 5. Credendino SC, Neumayer C, Cantone I. Genetics and epigenetics of sex bias: insights from human cancer and autoimmunity. Trends Genet. 36(9), 650–663 (2020).
    • 6. Emran AA, Gallagher SJ, Tiffen JC, Hersey P. Sex bias of females in survival from cancer and infections. Is X the answer? Br. J. Cancer. 124(7), 1184–1186 (2021).
    • 7. O'Keeffe LM, Taylor G, Huxley RR et al. Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis. BMJ Open. 8(10), e021611 (2018).
    • 8. Marocchio LS, Giudice F, Corrêa L et al. Oestrogens and androgen receptors in oral squamous cell carcinoma. Acta Odontol. Scand. 71(6), 1513–1519 (2013). • Discusses the role of sex hormones in oral cancer.
    • 9. Wu TF, Luo FJ, Chang YL et al. The oncogenic role of androgen receptors in promoting the growth of oral squamous cell carcinoma cells. Oral Dis. 21(3), 320–327 (2015). • Discusses the role of sex hormones in promoting the growth of oral cancer.
    • 10. Tomasovic-Loncaric C, Fucic A, Andabak A et al. Androgen receptor as a biomarker of oral squamous cell carcinoma progression risk. Anticancer Res. 39(8), 4285–4289 (2019). • Discusses the sex hormone as a biomarker in oral cancer progression.
    • 11. Shinn JR, Carey RM, Mady LJ et al. Sex-based differences in outcomes among surgically treated patients with HPV-related oropharyngeal squamous cell carcinoma. Oral Oncol. 123, DOI: 10.1016/j.oraloncology.2021.105570 (2021).
    • 12. Berman TA, Schiller JT. Human papillomavirus in cervical cancer and oropharyngeal cancer: one cause, two diseases. Cancer. 123(12), 2219–2229 (2017). • Discusses sex-bias in HPV-positive and HPV-negative OSSCC groups.
    • 13. Herrero R, Quint W, Hildesheim A et al. Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica. PLOS ONE. 8(7), e68329 (2013).
    • 14. Law CL, Qassim M, Thompson CH et al. Factors associated with clinical and sub-clinical anal human papillomavirus infection in homosexual men. Genitourin. Med. 67(2), 92–98 (1991).
    • 15. Abdel-Rahman O. Sex-based differences in outcomes of patients with HPV-positive versus HPV-negative oropharyngeal carcinoma: a population-based study. Expert Rev. Anticancer Ther. 20(9), 813–818 (2020). • Discusses effect of oral cancer sex-bias on clinical outcome.