Brain injury after cranial radiotherapy combined with immunotherapy for brain metastases in lung cancer: a retrospective study

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1. Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. J. Neurooncol. 75(1), 5–14 (2005).
  MedlineGoogle Scholar
• 2. Brastianos HC, Cahill DP, Brastianos PK. Systemic therapy of brain metastases. Curr. Neurol. Neurosci. Rep. 15(2), 518 (2015).
  MedlineGoogle Scholar
• 3. Ashrafizadeh M, Farhood B, Eleojo Musa A et al. Abscopal effect in radioimmunotherapy. Int. Immunopharmacol. 85, 106663 (2020).
  Medline CASGoogle Scholar
• 4. Fridman WH, Pagès F, Sautès-Fridman C et al. The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12(4), 298–306 (2012).
  Medline CASGoogle Scholar
• 5. Holmgaard RB, Zamarin D, Li Y et al. Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner. Cell Rep. 13(2), 412–424 (2015).
  Medline CASGoogle Scholar
• 6. Shaverdian N, Lisberg AE, Bornazyan K et al. Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial. Lancet Oncol. 18(7), 895–903 (2017).
  Medline CASGoogle Scholar
• 7. Petrelli F, De Stefani A, Trevisan F et al. Combination of radiotherapy and immunotherapy for brain metastases: a systematic review and meta-analysis. Crit. Rev. Oncol. Hematol. 144, 102830 (2019).
  MedlineGoogle Scholar
• 8. Ali FS, Arevalo O, Zorofchian S et al. Cerebral radiation necrosis: incidence, pathogenesis, diagnostic challenges, and future opportunities. Curr. Oncol. Rep. 21(8), 66 (2019).
  MedlineGoogle Scholar
• 9. Martin AM, Cagney DN, Catalano PJ et al. Immunotherapy and symptomatic radiation necrosis in patients with brain metastases treated with stereotactic radiation. JAMA Oncol. 4(8), 1123–1124 (2018). •• Retrospective study showing that immunotherapy was associated with symptomatic radiation necrosis (RN) in melanoma, which provided us with ideas for our research.
  MedlineGoogle Scholar
• 10. Diao K, Bian SX, Routman DM et al. Combination ipilimumab and radiosurgery for brain metastases: tumor, edema, and adverse radiation effects. J. Neurosurg. 129(6), 1397–1406 (2018).
  Medline CASGoogle Scholar
• 11. Moon SY, Yoon M, Chung M, Chung WK, Kim DW. Comparison of the extent of hippocampal sparing according to the tilt of a patient's head during WBRT using linear accelerator-based IMRT and VMAT. Phys Med. 32(5), 657–663 (2016).
  MedlineGoogle Scholar
• 12. Wang YX, King AD, Zhou H et al. Evolution of radiation-induced brain injury: MR imaging-based study. Radiology 254(1), 210–218 (2010). • Helped us evaluate and diagnose brain RN.
  MedlineGoogle Scholar
• 13. Healy SD. Animal cognition. Integr. Zool. 14(2), 128–131 (2019).
  MedlineGoogle Scholar
• 14. Fazekas F, Chawluk JB, Alavi A et al. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am. J. Roentgenol. 149(2), 351–356 (1987).
  Medline CASGoogle Scholar
• 15. Plevkova J, Brozmanova M, Matloobi A et al. Animal models of cough. Respir. Physiol. Neurobiol. 290, 103656 (2021).
  MedlineGoogle Scholar
• 16. Kim PH, Suh CH, Kim HS et al. Immune checkpoint inhibitor therapy may increase the incidence of treatment-related necrosis after stereotactic radiosurgery for brain metastases: a systematic review and meta-analysis. Eur. Radiol. 31(6), 4114–4129 (2021). • Study showing that in patients with brain metastases from melanoma, the incidence of RN was higher in those treated with stereotactic radiosurgery + immune checkpoint inhibitors than those receiving stereotactic radiosurgery alone.
  Medline CASGoogle Scholar
• 17. Shepard MJ, Xu Z, Donahue J et al. Stereotactic radiosurgery with and without checkpoint inhibition for patients with metastatic non-small cell lung cancer to the brain: a matched cohort study. J. Neurosurg. 133(3), 655–663 (2019).
  Google Scholar
• 18. Parvez K, Parvez A, Zadeh G. The diagnosis and treatment of pseudoprogression, radiation necrosis and brain tumor recurrence. Int. J. Mol. Sci. 15(7), 11832–11846 (2014).
  MedlineGoogle Scholar
• 19. Wen PY, Macdonald DR, Reardon DA et al. Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J. Clin. Oncol. 28(11), 1963–1972 (2010).
  MedlineGoogle Scholar
• 20. Pollock BE. Management of vestibular schwannomas that enlarge after stereotactic radiosurgery: treatment recommendations based on a 15 year experience. Neurosurgery 58(2), 241–248; discussion 241–248 (2006).
  MedlineGoogle Scholar
• 21. Mathis NJ, Wijetunga NA, Imber BS et al. Recent advances and applications of radiation therapy for brain metastases. Curr. Oncol. Rep. 24(3), 335–342 (2022).
  Medline CASGoogle Scholar
• 22. Maranzano E, Trippa F, Loreti F. Tumor relapse or radionecrosis after radiosurgery: single-photon emission computed tomography for differential diagnosis. In regard to Blonigen et al. Irradiated volume as a predictor of brain radionecrosis after linear accelerator stereotactic radiosurgery. (Int. J. Radiat. Oncol. Biol. Phys. 2010;77:996–1001). Int. J. Radiat. Oncol. Biol. Phys. 78(4), 1279 (2010).
  MedlineGoogle Scholar
• 23. Minniti G, Scaringi C, Clarke E et al. Frameless linac-based stereotactic radiosurgery (SRS) for brain metastases: analysis of patient repositioning using a mask fixation system and clinical outcomes. Radiat. Oncol. 6, 158 (2011).
  MedlineGoogle Scholar
• 24. Korytko T, Radivoyevitch T, Colussi V et al. 12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumors. Int. J. Radiat. Oncol. Biol. Phys. 64(2), 419–424 (2006).
  MedlineGoogle Scholar
• 25. Bauman GS, Sneed PK, Wara WM et al. Reirradiation of primary CNS tumors. Int. J. Radiat. Oncol. Biol. Phys. 36(2), 433–441 (1996). • Study showing that the incidence of RN at higher doses (78–94 Gy) could reach 17%, which is similar to the radiation dose in our study.
  Medline CASGoogle Scholar
• 26. Ruben JD, Dally M, Bailey M et al. Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int. J. Radiat. Oncol. Biol. Phys. 65(2), 499–508 (2006).
  MedlineGoogle Scholar
• 27. Prabhu RS, Press RH, Patel KR et al. Single-fraction stereotactic radiosurgery (SRS) alone versus surgical resection and SRS for large brain metastases: a multi-institutional analysis. Int. J. Radiat. Oncol. Biol. Phys. 99(2), 459–467 (2017).
  MedlineGoogle Scholar
• 28. Jeong WJ, Park JH, Lee EJ et al. Efficacy and safety of fractionated stereotactic radiosurgery for large brain metastases. J. Korean Neurosurg. Soc. 58(3), 217–224 (2015).
  Medline CASGoogle Scholar
• 29. Cerghet M, Redman B, Junck L et al. Prolonged survival after multifocal brain radiation necrosis associated with whole brain radiation for brain metastases: case report. J. Neurooncol. 90(1), 85–88 (2008).
  MedlineGoogle Scholar
• 30. Rammo R, Asmaro K, Schultz L et al. The safety of magnetic resonance imaging-guided laser interstitial thermal therapy for cerebral radiation necrosis. J. Neurooncol. 138(3), 609–617 (2018).
  MedlineGoogle Scholar
• 31. Rahmathulla G, Recinos PF, Valerio JE et al. Laser interstitial thermal therapy for focal cerebral radiation necrosis: a case report and literature review. Stereotact. Funct. Neurosurg. 90(3), 192–200 (2012).
  MedlineGoogle Scholar
• 32. Bowden GN, Kim JO, Faramand A et al. Clinical dose profile of gamma knife stereotactic radiosurgery for extensive brain metastases. J. Neurosurg. 134(5), 1430–1434 (2020).
  MedlineGoogle Scholar
• 33. Cheung MC, Chan AS, Law SC et al. Impact of radionecrosis on cognitive dysfunction in patients after radiotherapy for nasopharyngeal carcinoma. Cancer 97(8), 2019–2026 (2003).
  MedlineGoogle Scholar
• 34. De Reuck J, Auger F, Durieux N et al. Topographic distribution of white matter changes and lacunar infarcts in neurodegenerative and vascular dementia syndromes: a post-mortem 7.0-tesla magnetic resonance imaging study. Eur. Stroke J. 1(2), 122–129 (2016).
  MedlineGoogle Scholar
• 35. Colaco RJ, Martin P, Kluger HM et al. Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases? J. Neurosurg. 125(1), 17–23 (2016). •• Study showing that patients with RN have a longer survival, which is consistent with our conclusion.
  Medline CASGoogle Scholar