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The change of eosinophils in the perioperative period is significantly associated with the prognosis in patients with lung cancer

    Peng Dai‡

    Department of Thoracic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    ,
    Yanhong Wei‡

    Department of Rheumatology & Immunology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    ,
    Lecai Xiong

    Department of Thoracic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    ,
    Xiao Zhou

    Department of Thoracic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    ,
    Xuefeng Zhou

    Department of Thoracic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    ,
    Ming Xu

    Department of Thoracic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    ,
    Jinping Zhao

    *Author for correspondence: Tel.: +86 138 0869 9392;

    E-mail Address: zhaojpthx@126.com

    Department of Thoracic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    &
    Hexiao Tang

    **Author for correspondence: Tel.: +86 151 0272 3563;

    E-mail Address: thx1245@sina.com

    Department of Thoracic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    Published Online:https://doi.org/10.2217/fon-2022-0674

    Background: This research focuses on the relationship between the changes in peripheral blood eosinophils (PBEs) perioperatively and the prognosis of lung cancer. Methods: The study included 414 lung cancer patients. These patients were divided into the DOWN (186 patients) and UP (209 patients) groups according to perioperative changes in PBEs. Furthermore, overall survival was compared based on pathological stage, pathological type, tumor location, age and sex. Furthermore, the authors analyzed the prediction of PBEs on the prognosis of chemotherapy. Results: The results showed that lung cancer patients in the DOWN group had a better prognosis (p = 0.0121; 95% CI: 0.6915 [0.5184–0.9224]), and the DOWN group patients with normal postoperative PBEs had a better prognosis (p = 0.0115; 95% CI: 0.6721 [0.4938–0.9148]). Conclusion: Lung cancer patients whose postoperative PBEs were lower than preoperative PBEs had a better prognosis.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

    References

    • 1. Chansky K, Detterbeck FC, Nicholson AG et al. The IASLC Lung Cancer Staging Project: external validation of the revision of the TNM stage groupings in the eighth edition of the TNM Classification of Lung Cancer. J. Thorac. Oncol. 12(7), 1109–1121 (2017). • This may help explain why stage II patients are affected by peripheral blood eosinophil changes and those in stage I are not.
    • 2. Carretero R, Sektioglu IM, Garbi N et al. Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells. Nat. Immunol. 16(6), 609–617 (2015).
    • 3. Yang X, Wang L, Du H et al. Prognostic impact of eosinophils in peripheral blood and tumor site in patients with esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy. Medicine 100(3), e24328 (2021).
    • 4. Davis BP, Rothenberg ME. Eosinophils and cancer. Cancer Immunol. Res. 2(1), 1–8 (2014).
    • 5. Adamko DJ, Odemuyiwa SO, Vethanayagam D et al. The rise of the phoenix: the expanding role of the eosinophil in health and disease. Allergy 60(1), 13–22 (2005).
    • 6. Kita H. Eosinophils: multifaceted biological properties and roles in health and disease. Immunol. Rev. 242(1), 161–177 (2011).
    • 7. Munitz A, Levi-Schaffer F. Eosinophils: ‘new’ roles for ‘old’ cells. Allergy 59(3), 268–275 (2004).
    • 8. Simon SCS, Utikal J, Umansky V. Opposing roles of eosinophils in cancer. Cancer Immunol. Immunother. 68(5), 823–833 (2019).
    • 9. Rakesh N, Devi Y, Majumdar K et al. Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma. J. Clin. Exp. Dent. 7(1), e1–e6 (2015).
    • 10. Sachs E, Sartipy U, Jackson V. Sex and survival after surgery for lung cancer: a Swedish nationwide cohort. Chest 159(5), 2029–2039 (2021).
    • 11. Tang H, Liao Y, Xu L et al. Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice. Int. J. Cancer 133(10), 2473–2482 (2013). • This laid a theoretical foundation for the current study's gender-based grouping.
    • 12. Tang H, Liao Y, Chen G et al. Estrogen upregulates the IGF-1 signaling pathway in lung cancer through estrogen receptor-beta. Med. Oncol. 29(4), 2640–2648 (2012).
    • 13. Bai Y, Shen W, Zhang L et al. Oestrogen receptor beta5 and epidermal growth factor receptor synergistically promote lung cancer progression. Autoimmunity 51(4), 157–165 (2018).
    • 14. Ichinose Y, Kato H, Koike T et al. Completely resected stage IIIA non-small cell lung cancer: the significance of primary tumor location and N2 station. J. Thorac. Cardiovasc. Surg. 122(4), 803–808 (2001). • This laid a theoretical foundation for the current study's lobe-based grouping.
    • 15. Watanabe S, Suzuki K, Asamura H. Superior and basal segment lung cancers in the lower lobe have different lymph node metastatic pathways and prognosis. Ann. Thorac. Surg. 85(3), 1026–1031 (2008).
    • 16. Ettinger DS, Wood DE, Aisner DL et al. NCCN guidelines insights: non-small cell lung cancer, version 2.2021. JNCCN 19(3), 254–266 (2021).
    • 17. Zhang JT, Liu SY, Gao W et al. Longitudinal undetectable molecular residual disease defines potentially cured population in localized non-small cell lung cancer. Cancer Discov. doi:10.1158/2159-8290.CD-21-1486 OF1-OF12 (2022) (Epub ahead of print).
    • 18. Xia L, Mei J, Kang R et al. Perioperative ctDNA-based molecular residual disease detection for non-small cell lung cancer: a prospective multicenter cohort study (LUNGCA-1). Clin. Cancer Res. doi:10.1158/1078-0432.CCR-21-3044 (2021) (Epub ahead of print).
    • 19. Varricchi G, Galdiero MR, Loffredo S et al. Eosinophils: the unsung heroes in cancer? Oncoimmunology 7(2), e1393134 (2018).
    • 20. Steel JL, Kim KH, Dew MA et al. Cancer-related symptom clusters, eosinophils, and survival in hepatobiliary cancer: an exploratory study. J. Pain Symptom Manage. 39(5), 859–871 (2010).
    • 21. Cuschieri A, Talbot IC, Weeden S et al. Influence of pathological tumour variables on long-term survival in resectable gastric cancer. Br. J. Cancer 86(5), 674–679 (2002).
    • 22. Zhang Y, Ren H, Wang L et al. Clinical impact of tumor-infiltrating inflammatory cells in primary small cell esophageal carcinoma. Int. J. Mol. Sci. 15(6), 9718–9734 (2014).
    • 23. Riquet M, Rivera C, Pricopi C et al. Is the lymphatic drainage of lung cancer lobe-specific? A surgical appraisal. Eur. J. Cardiothorac. Surg. 47(3), 543–549 (2015). •• This may help explain why patients with tumors in the right lobe are affected by peripheral blood eosinophil changes and those in the left lobe are not.
    • 24. Zhao Y, Mao Y, He J et al. Lobe-specific lymph node dissection in clinical stage IA solid-dominant non-small-cell lung cancer: a propensity score matching study. Clin. Lung Cancer 22(2), e201–e210 (2021). •• This may help explain why patients with tumors in the right lobe are affected by peripheral blood eosinophil changes and those in the left lobe are not.
    • 25. Rothenberg ME. Eotaxin. An essential mediator of eosinophil trafficking into mucosal tissues. Am. J. Respir. Cell Mol. Biol. 21(3), 291–295 (1999).
    • 26. Shi HZ, Humbles A, Gerard C et al. Lymph node trafficking and antigen presentation by endobronchial eosinophils. J. Clin. Invest. 105(7), 945–953 (2000).
    • 27. Friend DS, Gurish MF, Austen KF et al. Senescent jejunal mast cells and eosinophils in the mouse preferentially translocate to the spleen and draining lymph node, respectively, during the recovery phase of helminth infection. J. Immunol. 165(1), 344–352 (2000).
    • 28. Oliveira DT, Biassi TP, Faustino SE et al. Eosinophils may predict occult lymph node metastasis in early oral cancer. Clin. Oral Investig. 16(6), 1523–1528 (2012).
    • 29. Geiger H, De Haan G, Florian MC. The ageing haematopoietic stem cell compartment. Nat. Rev. Immunol. 13(5), 376–389 (2013). • This may help explain why patients younger than 60 years old are affected by peripheral blood eosinophil changes and those older than 60 are not.
    • 30. Oh J, Lee YD, Wagers AJ. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat. Med. 20(8), 870–880 (2014).
    • 31. Conboy IM, Conboy MJ, Wagers AJ et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433(7027), 760–764 (2005). • This may help explain why patients younger than 60 years old are affected by peripheral blood eosinophil changes and those older than 60 are not.
    • 32. Riether C, Schurch CM, Ochsenbein AF. Regulation of hematopoietic and leukemic stem cells by the immune system. Cell Death Differ. 22(2), 187–198 (2015).
    • 33. Pioli PD, Casero D, Montecino-Rodriguez E et al. Plasma cells are obligate effectors of enhanced myelopoiesis in aging bone marrow. Immunity 51(2), 351–366 e356 (2019).
    • 34. Brigger D, Riether C, Van Brummelen R et al. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nat. Metab. 2(8), 688–702 (2020).
    • 35. Siroux V, Curt F, Oryszczyn MP et al. Role of gender and hormone-related events on IgE, atopy, and eosinophils in the epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy. J. Allergy Clin. Immunol. 114(3), 491–498 (2004).