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Effects of genetic polymorphisms of LINC-PINT gene on liver cancer susceptibility in the Chinese Han population

    Zhiwei Yu‡

    Department of Hepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China

    ‡Authors contributed equally

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    ,
    Shizong Li‡

    Department of Hepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Kaiqiong Wang

    Department of Hepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China

    ,
    Dongwei Gong

    Department of Hepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China

    ,
    Xin Qiao

    Department of Hepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China

    &
    Changxiong Wu

    *Author for correspondence:

    E-mail Address: wuchangxiong@hainmc.edu.cn

    Department of Hepatopancreatobiliary Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China

    Published Online:https://doi.org/10.2217/fon-2022-0669

    Objective: Liver cancer (LC) is the most common cause of cancer mortality. This study aimed to explore the impact of LINC-PINT polymorphisms on LC. Materials & methods: The authors recruited 591 LC patients and 592 healthy controls. The association between LINC-PINT polymorphisms and susceptibility to LC was determined by logistic regression analysis. Results: The authors found that rs157916 and rs16873842 reduced susceptibility to LC. rs157916 decreased LC risk in patients aged <55 years, nondrinkers and those with BMI <24. rs16873842 had a protective role against LC in patients aged ≥55 years, women, nonsmokers and those with BMI ≥24. rs7801029 decreased LC risk in patients with BMI <24. rs28662387 increased LC risk in women. Conclusion:LINC-PINT polymorphisms exert a protective effect against LC.

    Papers of special note have been highlighted as: •• of considerable interest

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