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Clinical significance of Notch pathway-associated microRNA-107 in pancreatic ductal adenocarcinoma

    Safoora Rashid

    Department of Gastroenterology & HNU, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Sumaira Rashid

    Department of Gastroenterology & HNU, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Prasenjit Das

    Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Nidhi Singh

    Department of Gastroenterology & HNU, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Nihar R Dash

    Department of GI Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Baibaswata Nayak

    Department of Gastroenterology & HNU, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Hem C Sati

    Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Shyam S Chauhan

    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India

    ,
    Surabhi Gupta

    Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, 110029, India

    &
    Anoop Saraya

    *Author for correspondence: Tel.: +91 112 659 3359,

    E-mail Address: ansaraya@yahoo.com

    Department of Gastroenterology & HNU, All India Institute of Medical Sciences, New Delhi, 110029, India

    Published Online:https://doi.org/10.2217/fon-2022-0356

    Background & aim: MicroRNAs associated with the Notch pathway play a critical role in the progression of pancreatic carcinoma. Our aim was to study the clinical significance of miR-107 and NOTCH2 in pancreatic ductal adenocarcinoma (PDAC). Methods: The circulating miR-107 levels in PDAC and controls were determined by qPCR. NOTCH2 protein (target) expression in tissue of PDAC, periampullary carcinoma, chronic pancreatitis and normal pancreatic tissue was assessed by immunohistochemistry. Results: The circulating miR-107 levels were found to be significantly reduced in PDAC as compared with controls. Additionally, NOTCH2 protein expression was higher in PDAC tissue as compared with controls and was clinically associated with metastasis. Conclusion: Our findings demonstrate the utility of circulating miR-107 as a potential differentiating marker in PDAC.

    Papers of special note have been highlighted as: • of interest

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