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Age-dependent prognostic value of KRAS mutation in metastatic colorectal cancer

    Muhammet Ozer

    Department of Internal Medicine, Capital Health Regional Medical Center, NJ 08638, USA

    Division of Hematology & Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA

    ,
    Suleyman Yasin Goksu

    Division of Hematology & Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA

    ,
    Nina Niu Sanford

    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA

    ,
    Chul Ahn

    Department of Population & Data Sciences, UT Southwestern Medical Center, Dallas, TX 75390, USA

    ,
    Muhammad Shaalan Beg

    Division of Hematology & Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA

    &
    Syed Mohammad Ali Kazmi

    *Author for correspondence: Tel.: +1 214 648 4180;

    E-mail Address: Syed.Kazmi@UTSouthwestern.edu

    Division of Hematology & Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA

    Published Online:https://doi.org/10.2217/fon-2021-0650

    Background: The age-dependent prognostic impact of KRAS status in metastatic colorectal cancer (mCRC) is unknown. Materials & Methods: We used the National Cancer Database to evaluate the survival by KRAS status for age-groups <50, 50–69 and ≥70, adjusting for relevant patient and tumor characteristics. Results: mCRC patients (n = 26,095; 33.5%) had KRAS status reported, and 11,338 of these patients (43.4%) had mutations in the KRAS gene. Patients with KRAS mutations had worse overall survival than wild-type KRAS patients. In age-groups <50 years (23 vs 29 months; p < 0.001) and 50–69 (21 vs 23.4 months; p < 0.001), KRAS mutations were significantly associated with worse survival, whereas in the ≥70-year age-group, there was no significant association (14 vs 14 months; p = 0.34). Conclusion: We conclude that the age of patients influences the prognostic value of KRAS mutation in metastatic colorectal cancer.

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