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The relationship between methionine synthase rs1805087 polymorphism and hematological cancers risk

    Yanliang Bai

    Department of Haematology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital Henan, 450003, Zhengzhou, PR China

    Department of Haematology, Henan University People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, 450003, Henan, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Emmanuel Kwateng Drokow

    Department of Radiation Oncology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital Henan, 450003, Zhengzhou, PR China

    Authors contributed equally

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    ,
    Hafiz Abdul Waqas Ahmed

    Department of Haematology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital Henan, 450003, Zhengzhou, PR China

    Authors contributed equally

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    ,
    Juanjuan Song

    Department of Haematology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital Henan, 450003, Zhengzhou, PR China

    ,
    Gloria Selorm Akpabla

    Department of Internal Medicine, Tianjin Medical University, 300070, Tianjin, PR China

    ,
    Maame Awoyoe Kumah

    Department of Internal Medicine, University of Ghana Medical School, KB 77 Korle Bu-Accra, Ghana

    ,
    Emmanuel Bamfo Agyekum

    School of Pharmacy, Zhengzhou University, 450001, Zhengzhou, Henan, PR China

    ,
    Enyonam Adjoa Neku

    School of Pharmacy, Zhengzhou University, 450001, Zhengzhou, Henan, PR China

    &
    Kai Sun

    *Author for correspondence: Tel.: +86 182 3711 0038;

    E-mail Address: sunkai@cellscience.org

    Department of Haematology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital Henan, 450003, Zhengzhou, PR China

    Department of Haematology, Henan University People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, 450003, Henan, PR China

    Published Online:https://doi.org/10.2217/fon-2020-0627

    Background: The relationship between hematological cancer susceptibility and methionine synthase MTR A2756G (rs1805087) polymorphism is inconclusive based on data from past studies. Hence, this updated meta-analysis was conducted to investigate the relationship between methionine synthase reductase (MTR) rs1805087 polymorphism and hematological cancers. Method: We searched EMBASE, Google Scholar, Ovid and PubMed databases for possible relevant articles up to December 31, 2019. Results: The overall pooled outcome of our analysis showed lack of association between the risk of hematological malignancies and MTR A2756G polymorphism under the allele model (G vs A: odds ratio = 1.001, 95% CI: 0.944–1.061; p = 0.983), recessive model (GG vs GA + AA: odds ratio = 1.050, 95% CI: 0.942–1.170; p = 0.382). Conclusion: The findings in this study demonstrate a lack of relationship between hematological cancers and MTR A2756G.

    Papers of special note have been highlighted as: • of interest

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