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Role of marital status on the prognosis in esophagus adenocarcinoma: a real-world competing risk analysis

    Tian Lan

    Department of Breast Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, Zhejiang, PR China

    The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, PR China

    ‡Authors contributed equally to this work

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    ,
    Weiguo Liu

    Department of Oncology, The People's Hospital of Jiangshan, Quzhou, 324100, Zhejiang, PR China

    ‡Authors contributed equally to this work

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    ,
    Yunyan Lu

    Department of Cardiology, The First People's Hospital of Xiaoshan District, Hangzhou, 311201, Zhejiang, PR China

    ‡Authors contributed equally to this work

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    ,
    Ruzhen Zheng

    Department of Radiotherapy, Hangzhou Cancer Hospital, Hangzhou, 310002, Zhejiang, PR China

    ,
    Hua Luo

    Department of Breast Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, Zhejiang, PR China

    ,
    Xiying Shao

    Department of Medical Oncology (Breast), Cancer Hospital of the University of Chinese Academy of Sciences; Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, PR China

    &
    Junling He

    *Author for correspondence: Tel.: +861 339 571 8907;

    E-mail Address: hjlcyq@163.com

    Department of Breast Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, Zhejiang, PR China

    Published Online:https://doi.org/10.2217/fon-2020-0613

    Aim: The purpose of this study was to assess the role of marital status in esophageal adenocarcinoma (EAC). Methods: We identified 8341 EAC patients based on the Surveillance, Epidemiology and End Results database during 2007–2015, of whom 7275 were male and 1066 were female. Temporal trends, competing risk analysis and propensity score matching were performed. Results: There was an upward trend for the rate of unmarried patients in both male and female populations (p < 0.05). Unmarried status represented an independent risk factor for higher cancer-specific death (CSD) in males (hazard ratio: 1.11; 95% CI: 1.04–1.18; p = 0.001) but not in females (hazard ratio: 0.96; 95% CI: 0.81–1.13; p = 0.610). Married EAC patients experienced lower CSD compared with their unmarried counterparts in the male cohort.

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