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Research ArticleOpen Accesscc iconby iconnc iconnd icon

Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1

    Kosuke Narumiya

    *Author for correspondence: Tel.: +81 3 3353 8111; Fax: +81 3 5269 7507;

    E-mail Address: narumiya.ige@twmu.ac.jp

    Department of Surgery, Institute of Gastroenterology, Tokyo Women’s Medical University, Kawada 8-1, Shinjyuku, Tokyo, 1628666, Japan

    ,
    Elfriede Bollschweiler

    Medical Faculty, University of Cologne, Kerpener Str. 62, Cologne, 50924, Germany

    ,
    Arnulf H Hölscher

    Medical Faculty, University of Cologne, Kerpener Str. 62, Cologne, 50924, Germany

    Head Contilia Center for Esophageal Diseases, Elisabeth Hospital, Klara-Kopp-Weg 1, Essen, 45138, Germany

    ,
    Masakazu Yamamoto

    Department of Surgery, Institute of Gastroenterology, Tokyo Women’s Medical University, Kawada 8-1, Shinjyuku, Tokyo, 1628666, Japan

    ,
    Uta Drebber

    Institute of Pathology, University of Cologne, Kerpener Str. 62, Cologne, 50924, Germany

    ,
    Hakan Alakus

    Department of General, Visceral & Cancer Surgery, University of Cologne, Kerpner Str. 62, Cologne, 50924, Germany

    ,
    Ralf Metzger

    Department of General, Visceral, Thoracic & Cancer Surgery, Caritas Klinikum, Rhine Str. 2, Saarbrücken, 66113, Germany

    &
    Ute Warnecke-Eberz

    Department of General, Visceral & Cancer Surgery, University of Cologne, Kerpner Str. 62, Cologne, 50924, Germany

    Published Online:https://doi.org/10.2217/fon-2020-0489

    Aim: To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. Results: The distribution of the genotypes of ERCC1 rs16115 and ABCB1 C3435T rs1045642 was significantly different between both patients’ groups. Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Conclusion: Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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