Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma

References

• 1. Wallace MC, Preen D, Jeffrey GP et al. The evolving epidemiology of hepatocellular carcinoma: a global perspective. Expert Rev. Gastroenterol. Hepatol. 9(6), 765–779 (2015).
  Medline CASGoogle Scholar
• 2. Bray F, Ferlay J, Soerjomataram I et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68(6), 394–424 (2018).
  MedlineGoogle Scholar
• 3. Chen W, Zheng R, Baade PD et al. Cancer statistics in China, 2015. CA Cancer J. Clin. 66(2), 115–132 (2016).
  MedlineGoogle Scholar
• 4. Le VQ, Nguyen VH, Nguyen VH et al. Epidemiological characteristics of advanced hepatocellular carcinoma in the northern region of Vietnam. Cancer Control 26(1), 1073274819862793 (2019).
  Google Scholar
• 5. Benfeitas R, Uhlen M, Nielsen J et al. New challenges to study heterogeneity in cancer redox metabolism. Front. Cell Dev. Biol. 5, 65 (2017).
  MedlineGoogle Scholar
• 6. Tran HT, Anderson LH, Knight JD. Membrane-binding cooperativity and coinsertion by C2AB tandem domains of synaptotagmins 1 and 7. Biophys. J. 116(6), 1025–1036 (2019).
  Medline CASGoogle Scholar
• 7. Wang S, Li Y, Ma C. Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion. eLife 5, e14211 (2016).
  MedlineGoogle Scholar
• 8. Cortes J, Hidalgo J, Aguilera S et al. Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren’s syndrome patients. J. Autoimmun. 97, 88–99 (2019).
  Medline CASGoogle Scholar
• 9. Turecek J, Regehr WG. Neuronal regulation of fast synaptotagmin isoforms controls the relative contributions of synchronous and asynchronous release. Neuron 101(5), 938–949.e4 (2019).
  Medline CASGoogle Scholar
• 10. Huang C, Walker EM, Dadi PK et al. Synaptotagmin 4 regulates pancreatic beta cell maturation by modulating the Ca⁽²⁺⁾ sensitivity of insulin secretion vesicles. Dev. Cell 45(3), 347–361.e5 (2018).
  Medline CASGoogle Scholar
• 11. Park J, Park SJ, Kim S. Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain. Mol. Brain 12(1), 58 (2019).
  MedlineGoogle Scholar
• 12. Duran E, Montes MA, Jemal I et al. Synaptotagmin-7 controls the size of the reserve and resting pools of synaptic vesicles in hippocampal neurons. Cell Calcium 74, 53–60 (2018).
  Medline CASGoogle Scholar
• 13. MacDougall DD, Lin Z, Chon NL et al. The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis. J. Gen. Physiol. 150(6), 783–807 (2018).
  Medline CASGoogle Scholar
• 14. Dolai S, Xie L, Zhu D et al. Synaptotagmin-7 functions to replenish insulin granules for exocytosis in human islet beta-cells. Diabetes 65(7), 1962–1976 (2016).
  Medline CASGoogle Scholar
• 15. Svec D, Tichopad A, Novosadova V et al. How good is a PCR efficiency estimate: recommendations for precise and robust qPCR efficiency assessments. Biomol. Detect. Quantif. 3, 9–16 (2015).
  Medline CASGoogle Scholar
• 16. Zhang W, Luo E, Gan J et al. Long-term survival of hepatocellular carcinoma after percutaneous radiofrequency ablation guided by ultrasound. World J. Surg. Oncol. 15(1), 122 (2017).
  MedlineGoogle Scholar
• 17. Zhang X, Li C, Wen T et al. Appropriate treatment strategies for intrahepatic recurrence after curative resection of hepatocellular carcinoma initially within the Milan criteria: according to the recurrence pattern. Eur. J. Gastroenterol. Hepatol. 27(8), 933–940 (2015).
  MedlineGoogle Scholar
• 18. Heimbach JK, Kulik LM, Finn RS et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology 67(1), 358–380 (2018).
  MedlineGoogle Scholar
• 19. Pang Q, Zhou L, Qu K et al. Validation of inflammation-based prognostic models in patients with hepatitis B-associated hepatocellular carcinoma: a retrospective observational study. Eur. J. Gastroenterol. Hepatol. 30(1), 60–70 (2018).
  Medline CASGoogle Scholar
• 20. Ji F, Liang Y, Fu S et al. Prognostic value of combined preoperative prognostic nutritional index and body mass index in HCC after hepatectomy. HPB (Oxford) 19(8), 695–705 (2017).
  MedlineGoogle Scholar
• 21. Chen DH, Wu QW, Li XD et al. SYPL1 overexpression predicts poor prognosis of hepatocellular carcinoma and associates with epithelial-mesenchymal transition. Oncol. Rep. 38(3), 1533–1542 (2017).
  Medline CASGoogle Scholar
• 22. Peng X, Moore M, Mathur A et al. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis. FASEB J. 30(12), 4056–4070 (2016).
  Medline CASGoogle Scholar
• 23. Xiao B, Li J, Fan Y et al. Downregulation of SYT7 inhibits glioblastoma growth by promoting cellular apoptosis. Mol. Med. Rep. 16(6), 9017–9022 (2017).
  Medline CASGoogle Scholar
• 24. Kanda M, Tanaka H, Shimizu D et al. SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells. Oncogene 37(39), 5355–5366 (2018).
  Medline CASGoogle Scholar
• 25. Wang K, Xiao H, Zhang J et al. Synaptotagmin7 is overexpressed in colorectal cancer and regulates colorectal cancer cell proliferation. J. Cancer 9(13), 2349–2356 (2018).
  MedlineGoogle Scholar
• 26. Fei Z, Gao W, Xie R et al. Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. Biosci. Rep. 39(2), BSR20181298 (2019).
  Medline CASGoogle Scholar
• 27. Jin H, Xu G, Zhang Q et al. Synaptotagmin-7 is overexpressed in hepatocellular carcinoma and regulates hepatocellular carcinoma cell proliferation via Chk1-p53 signaling. Onco Targets Ther. 10, 4283–4293 (2017).
  MedlineGoogle Scholar
• 28. Zhang B, Zhang B, Zhang Z et al. 42,573 cases of hepatectomy in China: a multicenter retrospective investigation. Sci. China Life Sci. 61(6), 660–670 (2018).
  Medline CASGoogle Scholar