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Research Article

Preoperative high c-reactive protein/albumin ratio is a poor prognostic factor of oral squamous cell carcinoma

    Qiuju Wang‡

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

    ‡Authors contributed equally

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    ,
    Xiaoyu Song‡

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

    ‡Authors contributed equally

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    ,
    Yanzhen Zhao

    The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China

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    ,
    Qiao He

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

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    ,
    Min Shi

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

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    ,
    Pingyao Xu

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

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    ,
    Sujiao Ni

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

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    ,
    Yibo Chen

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

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    ,
    Jingying Lin

    West China Second University Hospital, Sichuan University, & The Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, Chengdu, PR China

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    &
    Li Zhang

    *Author for correspondence: Tel.: +028 85420344; Fax: +028 85420344;

    E-mail Address: 13308216138@163.com

    Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science & Technology of China, Chengdu, PR China

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    Published Online:25 Jun 2019https://doi.org/10.2217/fon-2019-0063

    Abstract

    Aim: To explore whether c-reactive protein/albumin (CRP/Alb) ratio is a poor prognostic factor for patients with oral squamous cell carcinoma (OSCC). Patients & methods: Receiver-operating characteristic analysis was performed to evaluate the optimal cut-off value of CRP/Alb ratio in 240 patients with OSCC. The Kaplan–Meier method was used to plot the overall survival and disease-free survival curves. Cox proportional hazards model was used to implement univariate and multivariate analyses. Results: Preoperative high CRP/Alb ratio was associated with age, advanced stage, lymphatic metastasis, platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio (all p < 0.05). Elevated CRP/Alb ratio independently predicts worse overall survival and disease-free survival of patients with OSCC. Conclusion: Preoperative high CRP/Alb ratio was a poor independent prognostic marker of OSCC.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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