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Short Communication

High NUP43 expression might independently predict poor overall survival in luminal A and in HER2+ breast cancer

    Chao Tian

    Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, PR China

    Department of Breast, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Shijie Zhou

    Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, PR China

    Authors contributed equally

    Search for more papers by this author

    &
    Cheng Yi

    *Author for correspondence:

    E-mail Address: hxtc2000@163.com

    Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, PR China

    Published Online:https://doi.org/10.2217/fon-2017-0690

    Aim: To explore the independent prognostic value of NUP43 in terms of overall survival (OS) and the mechanisms of its dysregulation in breast cancer. Patients & methods: Bioinformatic analysis was performed by using data from The Cancer Genome Atlas-breast invasive carcinoma. Results: High NUP43 expression was an independent prognostic factor of poor OS in luminal A subtype (HR: 2.400; 95% CI: 1.070–5.379; p = 0.034) and in HER2+ subtype (HR: 10.578; 95% CI: 1.850–60.473; p = 0.008). NUP43 DNA amplification was associated with elevated NUP43 expression, while DNA deletion was associated with decreased NUP43 transcription. Conclusion:NUP43 upregulation was related to DNA amplification and might independently predict poor OS in luminal A and in HER2+ breast tumors.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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