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Computed tomography densitometric study of anti-angiogenic effect of regorafenib in colorectal cancer liver metastasis

    Alfonso Reginelli

    *Author for correspondence:

    E-mail Address: alfonsoreginelli@hotmail.com

    Department of Radiology & Radiotherapy, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, Piazza Miraglia 2, 80138 Naples, Italy

    ,
    Alfredo Clemente

    Department of Radiology & Radiotherapy, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, Piazza Miraglia 2, 80138 Naples, Italy

    ,
    Claudia Cardone

    Department of Medical Oncology, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, 80131 Naples, Italy

    ,
    Fabrizio Urraro

    Department of Radiology & Radiotherapy, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, Piazza Miraglia 2, 80138 Naples, Italy

    ,
    Andrea Izzo

    Department of Radiology & Radiotherapy, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, Piazza Miraglia 2, 80138 Naples, Italy

    ,
    Erika Martinelli

    Department of Medical Oncology, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, 80131 Naples, Italy

    ,
    Teresa Troiani

    Department of Medical Oncology, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, 80131 Naples, Italy

    ,
    Fortunato Ciardiello

    Department of Medical Oncology, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, 80131 Naples, Italy

    ,
    Luca Brunese

    Department of Medicine & Health Science ‘V Tiberio’, University of Molise, Campobasso, Italy

    &
    Salvatore Cappabianca

    Department of Radiology & Radiotherapy, Department of Internal & Experimental Medicine ‘F Magrassi’, Università degli Studi della Campania ‘L Vanvitelli’, Piazza Miraglia 2, 80138 Naples, Italy

    Published Online:https://doi.org/10.2217/fon-2017-0687

    Aim: Regorafenib induces radiological changes in liver metastasis among patients with metastatic colorectal cancer (mCRC). The standard criteria used to evaluate solid tumor response (Response Evaluation Criteria in Solid Tumors) may be limited in assessing response to biologic agents with anti-angiogenic action. Patients & methods: A total of 67 hepatic lesions in 32 selected patients were analyzed to evaluate tumor attenuation as measured by Hounsfield unit (HU) and size changes. Results: Following two cycles of regorafenib, tumor HU values decreased in the in 73.1% (49/67) of lesions (average HU changes -25.6%) while tumor size increased in 64.2% (43/67) of them (average size changes +25.4%). Conclusion: The computed tomography density changes evaluation may be an additional tool, in combination with tumor sizing, to evaluate tumor response in patients treated with regorafenib.

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