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New drugs and other strategies for the treatment of fungal infections

    Rodrigo Almeida-Paes

    Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, 21040-360, Brazil

    Rede Micologia – FAPERJ, Rio de Janeiro, 21941-902, Brazil

    &
    Susana Frases

    *Author for correspondence: Tel.: +21 3938 6564;

    E-mail Address: susanafrases@biof.ufrj.br

    Rede Micologia – FAPERJ, Rio de Janeiro, 21941-902, Brazil

    Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brasil

    Published Online:https://doi.org/10.2217/fmb-2023-0169
    Free first page

    References

    • 1. Qadri H, Shah AH, Mir M. Novel strategies to combat the emerging drug resistance in human pathogenic microbes. Curr. Drug Targets 22(12), 1424–1436 (2021).
    • 2. Rodrigues ML, Nosanchuk JD. Fungal diseases as neglected pathogens: a wake-up call to public health officials. PLoS Negl. Trop. Dis. 14(2), e0007964 (2020).
    • 3. Hoenigl M, Sprute R, Egger M et al. The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin. Drugs 81(15), 1703–1729 (2021).
    • 4. Aggarwal R, Targhotra M, Kumar B, Sahoo PK, Chauhan MK. Treatment and management strategies of onychomycosis. J. Mycol. Med. 30(2), 100949 (2020).
    • 5. Iyer KR, Revie NM, Fu C, Robbins N, Cowen LE. Treatment strategies for cryptococcal infection: challenges, advances and future outlook. Nat. Rev. Microbiol. 19(7), 454–466 (2021).
    • 6. Carpouron JE, de Hoog S, Gentekaki E, Hyde KD. Emerging animal-associated fungal diseases. J. Fungi. (Basel) 8(6), 611 (2022).
    • 7. Chaves AFA, Xander P, Romera LMD, Fonseca FLA, Batista WL. What is the elephant in the room when considering new therapies for fungal diseases? Crit. Rev. Microbiol. 47(3), 275–289 (2021).
    • 8. Curto MÁ, Butassi E, Ribas JC, Svetaz LA, Cortés JCG. Natural products targeting the synthesis of β(1,3)-D-glucan and chitin of the fungal cell wall. Existing drugs and recent findings. Phytomedicine 88, 153556 (2021).
    • 9. Almeida MA, Bernardes-Engemann AR, Coelho RA et al. Mebendazole inhibits histoplasma capsulatum in vitro growth and decreases mitochondrion and cytoskeleton protein levels. J. Fungi. (Basel) 9(3), 385 (2023).
    • 10. Campoy S, Adrio JL. Antifungals. Biochem. Pharmacol. 133, 86–96 (2017).
    • 11. Souza ACO, Amaral AC. Antifungal therapy for systemic mycosis and the nanobiotechnology era: improving efficacy, biodistribution and toxicity. Front Microbiol. 8, 336 (2017).
    • 12. Su S, Yan H, Min L et al. The antifungal activity of caspofungin in combination with antifungals or non-antifungals against Candida species in vitro and in clinical therapy. Expert Rev. Anti. Infect. Ther. 20(2), 161–178 (2022).
    • 13. Zhang J, Lin P, Li J, Guo C, Zhai J, Zhang Y. Efficacy of laser therapy combined with topical antifungal agents for onychomycosis: a systematic review and meta-analysis of randomised controlled trials. Lasers Med. Sci. 37(6), 2557–2569 (2022).
    • 14. Kokoska L, Kloucek P, Leuner O, Novy P. Plant-derived products as antibacterial and antifungal agents in human health care. Curr. Med. Chem. 26(29), 5501–5541 (2019).
    • 15. Passero LFD, Cavallone IN, Belda W. Reviewing the etiologic agents, microbe-host relationship, immune response, diagnosis, and treatment in chromoblastomycosis. J. Immunol. Res. 2021, 9742832 (2021).
    • 16. Candel FJ, Peñuelas M, Tabares C et al. Fungal infections following treatment with monoclonal antibodies and other immunomodulatory therapies. Rev. Iberoam. Micol. 37(1), 5–16 (2020).
    • 17. Teixeira MM, Almeida-Paes R, Bernardes-Engemann AR et al. Single nucleotide polymorphisms and chromosomal copy number variation may impact the Sporothrix brasiliensis antifungal susceptibility and sporotrichosis clinical outcomes. Fungal Genet Biol. 163, 103743 (2022).
    • 18. Shishodia SK, Tiwari S, Shankar J. Resistance mechanism and proteins in Aspergillus species against antifungal agents. Mycology 10(3), 151–165 (2019).
    • 19. Silva DR, Sardi J de CO, Freires IA, Silva ACB, Rosalen PL. In silico approaches for screening molecular targets in Candida albicans: a proteomic insight into drug discovery and development. Eur. J. Pharmacol. 842, 64–69 (2019).