Antimicrobial therapy using VIS plus water-filtered infrared-A as an alternative method to treat oral diseases
Abstract
Oral biofilm is the main cause of pathologies affecting the hard and soft oral tissues around teeth. Its main components are the periodontal pathogens and other bacteria of the supragingival and subgingival biofilm. Different alternative strategies that could be adjuvants to the usual periodontal treatments used to eliminate biofilms are available. One of these methods is antimicrobial photodynamic therapy using VIS and water-filtered infrared-A combined with a photosensitizer. In this review, different recent studies were collected to evaluate the antimicrobial effects of antimicrobial photodynamic therapy and the effectiveness of different types of photosensitizers.
Plain language summary
This review summarizes different types of photodynamic therapy, a type of treatment that uses light to kill cells, which can be used to decontaminate the mouth and teeth. There are many bacteria in our mouths and on the surface of our teeth that can cause infections, such as dental caries, periodontitis and peri-implantitis. This review also looks at how effective these treatments are and suggests the use of clinical trials to confirm our findings.
Papers of special note have been highlighted as: • of interest
References
- 1. Photoinactivation using visible light plus water-filtered infrared-A (vis + wIRA) and chlorine e6 (Ce6) eradicates planktonic periodontal pathogens and subgingival biofilms. Front. Microbiol. 7, 1900 (2016). • Explains the physiopathology of biofilm and the mechanism of action of antimicrobial photodynamic therapy (aPDT).
- 2. . Generation of inflammatory stimuli: how bacteria set up inflammatory responses in the gingiva. J. Clin. Periodontol. 32(Suppl. 6), 57–71 (2005).
- 3. . Periodontitis: a polymicrobial disruption of host homeostasis. Nat. Rev. Microbiol. 8, 481–490 (2010).
- 4. . Subgingival microbiota in individuals with severe chronic periodontitis. J. Microbiol. Immunol. Infect. 51(2), 226–234 (2018).
- 5. . Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema denticola / Prevotella intermedia co-infection are associated with severe periodontitis in a Thai population. PLoS One 10(8), e0136646 (2015).
- 6. Oral microbiota features in subjects with Down syndrome and periodontal diseases: a systematic review. Int. J. Mol. Sci. 22(19), 9251 (2021).
- 7. Antimicrobial photodynamic therapy – what we know and what we don't. Crit. Rev. Microbiol. 44(5), 571–589 (2018). • Explains the physiopathology of biofilm and the mechanism of action of aPDT.
- 8. Subinhibitory antibiotic concentrations enhance biofilm formation of clinical Enterococcus faecalis isolates. Antibiotics (Basel) 10(7), 874 (2021). • Explains the mechanisms of antibiotic resistance.
- 9. . The biofilm matrix. Nat. Rev. Microbiol. 8(9), 623–633 (2010). • Useful for understanding biofilm structure.
- 10. Alcohol-free essential oils containing mouthrinse efficacy on three-day supragingival plaque regrowth: a randomized crossover clinical trial. Trials 18(1), 154 (2017).
- 11. Effects of single rinse with three different types of mouthwashes on VSCs levels in morning breath: randomized, double-blind, crossover clinical trial. Int. J. Dent. Hyg. 21(2), 417–425 (2022).
- 12. . Commercial oral hygiene products and implant collar surfaces: scanning electron microscopy observations. Can. J. Dent. Hyg. 54(1), 26–31 (2020).
- 13. Use of electrical field for biofilm implant removal. Eur. Rev. Med. Pharmacol. Sci. 27(Suppl. 3), 114–121 (2023).
- 14. Photoantimicrobials – are we afraid of the light? Lancet Infect. Dis. 17(2), e49–e55 (2017).
- 15. . Definition of type I and type II photosensitized oxidation. Photochem. Photobiol. 54(5), 659 (1991).
- 16. . Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens. Front. Microbiol. 5, 405 (2014).
- 17. . Antibacterial photodynamic therapy in dermatology. Photochem. Photobiol. Sci. 3(10), 907–917 (2004).
- 18. . New photosensitizers for photodynamic therapy. Biochem. J. 473(4), 347–364 (2016).
- 19. . Photosensitizers in antibacterial photodynamic therapy: an overview. Laser Ther. 27(4), 293–302 (2018).
- 20. . An insight on bacterial cellular targets of photodynamic inactivation. Future Med. Chem. 6(2), 141–164 (2014).
- 21. . Antimicrobial photodynamic therapy (aPDT) for biofilm treatments. Possible synergy between aPDT and pulsed electric fields. Virulence 12(1), 2247–2272 (2021). • Important for understanding the potential of new technologies in biofilm treatments.
- 22. Novel broad-spectrum antimicrobial photoinactivation of in situ oral biofilms by visible light plus water-filtered infrared A. Appl. Environ. Microbiol. 80(23), 7324–7336 (2014).
- 23. LED antimicrobial photodynamic therapy with phenothiazinium dye against Staphylococcus aureus: an in vitro study. J. Photochem. Photobiol. B 175, 46–50 (2017).
- 24. . Antimicrobial photodynamic therapy using visible light plus water-filtered infrared-A (wIRA). J. Med. Microbiol. 62(Pt 3), 467–473 (2013).
- 25. . Randomized clinical trial of the influence of local water-filtered infrared A irradiation on wound healing after abdominal surgery. Br. J. Surg. 93(8), 952–960 (2006).
- 26. Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green. Future Med. Chem. 11(14), 1721–1739 (2019).
- 27. Antimicrobial photoinactivation using visible light plus water-filtered infrared-A (VIS + wIRA) alters in situ oral biofilms. PLoS One 10(7), e0132107 (2015).
- 28. . Microbial composition of oral biofilms after visible light and water-filtered infrared A radiation (VIS+wIRA) in combination with indocyanine green (ICG) as photosensitizer. Antibiotics (Basel) 9(9), 532 (2020).
- 29. . Antimicrobial behavior and cytotoxicity of indocyanine green in combination with visible light and water-filtered infrared A radiation against periodontal bacteria and subgingival biofilm. Biomedicines 10(5), 956 (2022).
- 30. Antimicrobial photoinactivation using visible light plus water-filtered infrared-A (VIS + wIRA) and Hypericum perforatum modifies in situ oral biofilms. Sci. Rep. 9(1), 20325 (2019).
- 31. . Antimicrobial photoinactivation of in situ oral biofilms by visible light plus water-filtered infrared A and tetrahydroporphyrin-tetratosylate (THPTS). Microorganisms 9(1), 145 (2021).
- 32. . Antimicrobial photodynamic treatment with mother juices and their single compounds as photosensitizers. Nutrients 13(3), 710 (2021).
- 33. . The oral microbiota: dynamic communities and host interactions. Nat. Rev. Microbiol. 16(12), 745–759 (2018).
- 34. . Biogeography of a human oral microbiome at the micron scale. Proc. Natl Acad. Sci. USA 113(6), e791–e800 (2016).
- 35. . Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction. J. Clin. Invest. 39(4), 592–600 (1960).
- 36. Synergistic photothermal and photodynamic therapy for effective implant-related bacterial infection elimination and biofilm disruption using Cu9S8 nanoparticles. ACS Biomater. Sci. Eng. 5(11), 6243–6253 (2019).
- 37. Enhanced antibacterial activity of indocyanine green-loaded graphene oxide via synergistic contact killing, photothermal and photodynamic therapy. J. Biomed. Nanotechnol. 18(1), 185–192 (2022).
- 38. Ti3C2Tx MXene loaded with indocyanine green for synergistic photothermal and photodynamic therapy for drug-resistant bacterium. Colloids Surf. B Biointerfaces 217, 112663 (2022).
- 39. Photothermal-driven disassembly of naphthalocyanine nano-photosensitizers for photothermal and photodynamic therapy. J. Colloid Interface Sci. 647, 201–210 (2023).
- 40. Adjuvant transgingival therapy with visible light plus water-filtered infrared-A (VIS + wIRA) in periodontal therapy – a randomized, controlled, stratified, double-blinded clinical trial. Antibiotics (Basel) 10(3), 251 (2021).
- 41. . Clinical applications of antimicrobial photodynamic therapy in dentistry. Front. Microbiol. 13, 1020995 (2023).