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Micro- and nanoparticles as platforms for the treatment of fungal infections: present and future perspectives

    Alessandro F Valdez

    Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Góes, Departamento de Microbiologia Geral, Rio de Janeiro – RJ, 21941-902, Brazil

    Departments of Medicine (Division of Infectious Diseases) & Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    ,
    Daniel Zamith-Miranda

    Departments of Medicine (Division of Infectious Diseases) & Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    ,
    Leonardo Nimrichter

    Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Góes, Departamento de Microbiologia Geral, Rio de Janeiro – RJ, 21941-902, Brazil

    Rede Micologia RJ, FAPERJ, Rio de Janeiro – RJ, 21941-902, Brazil

    &
    Joshua D Nosanchuk

    *Author for correspondence:

    E-mail Address: josh.nosanchuk@einsteinmed.edu

    Departments of Medicine (Division of Infectious Diseases) & Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Published Online:https://doi.org/10.2217/fmb-2023-0079
    Free first page

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

    References

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    • 19. Cleare LG, Li KL, Abuzeid WM, Nacharaju P, Friedman JM, Nosanchuk JD. NO Candida auris: nitric oxide in nanotherapeutics to combat emerging fungal pathogen Candida auris. J. Fungi. 6(2), 85 (2020). •• Investigated the potential of NO-NPs as an antifungal agent against the emerging fungal pathogen Candida auris. This paper is of fundamental importance because it is, to our knowledge, the first and only study so far to evaluate the effect NO-NPs against C. auris, a novel multi-resistant human pathogen. Although further research in the field is needed, this study successful demonstrates the potential of NO-NPs as a therapeutic option against C. auris.
    • 20. Liu S, Zamith-Miranda D, Almeida-Paes R, da Silva LBR, Nacharaju P, Nosanchuk JD. Nitric oxide-loaded nano- and microparticle platforms serving as potential new antifungal therapeutics. Fungal Biol. (2023). https://www.sciencedirect.com/science/article/pii/S1878614623000077