Systems biology of disease tolerance to malaria

References

• 1. Carter R, Mendis KN. Evolutionary and historical aspects of the burden of malaria. Clin. Microbiol. Rev. 15(4), 564–594 (2002).
  MedlineGoogle Scholar
• 2. de Jong SE, van Unen V, Manurung MD et al. Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity. Nat. Immunol. 22(5), 654–665 (2021).
  Medline CASGoogle Scholar
• 3. Gupta S, Snow RW, Donnelly CA, Marsh K, Newbold C. Immunity to non-cerebral severe malaria is acquired after one or two infections. Nat. Med. 5(3), 340–343 (1999).
  Medline CASGoogle Scholar
• 4. Tran TM, Guha R, Portugal S et al. A molecular signature in blood reveals a role for p53 in regulating malaria-induced inflammation. Immunity 51(4), 750–765; e10 (2019).
  Medline CASGoogle Scholar
• 5. Studniberg SI, Ioannidis LJ, Utami RAS et al. Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria. Mol. Syst. Biol. 18(4), e10824 (2022).
  Medline CASGoogle Scholar
• 6. Nahrendorf W, Ivens A, Spence PJ. Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria. eLife 10, e63838 (2021).
  Medline CASGoogle Scholar
• 7. Gozzelino R, Andrade BB, Larsen R et al. Metabolic adaptation to tissue iron overload confers tolerance to malaria. Cell Host Microbe 12(5), 693–704 (2012).
  Medline CASGoogle Scholar
• 8. Ramos S, Carlos AR, Sundaram B et al. Renal control of disease tolerance to malaria. Proc. Natl Acad. Sci. USA 116(12), 5681–5686 (2019).
  Medline CASGoogle Scholar
• 9. Wang A, Huen SC, Luan HH et al. Glucose metabolism mediates disease tolerance in cerebral malaria. Proc. Natl Acad. Sci. USA 115(43), 11042–11047 (2018).
  Medline CASGoogle Scholar
• 10. Cumnock K, Gupta AS, Lissner M, Chevee V, Davis NM, Schneider DS. Host energy source is important for disease tolerance to malaria. Curr. Biol. 28(10), 1635–1642; e3 (2018).
  Medline CASGoogle Scholar
• 11. Rodriguez-Muñoz D, Sánchez Á, Pérez-Benavente S et al. Hypothyroidism confers tolerance to cerebral malaria. Sci. Adv. 8(14), eabj7110 (2022).
  Medline CASGoogle Scholar
• 12. Vandermosten L, Pham T-T, Knoops S et al. Adrenal hormones mediate disease tolerance in malaria. Nat. Commun. 9(1), 4525 (2018).
  MedlineGoogle Scholar
• 13. Gordon EB, Hart GT, Tran TM et al. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proc. Natl Acad. Sci. USA 112(42), 13075–13080 (2015).
  Medline CASGoogle Scholar
• 14. Mejia P, Treviño-Villarreal JH, Hine C et al. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nat. Commun. 6(1), 6050 (2015).
  MedlineGoogle Scholar
• 15. Jagannathan P, Kim CC, Greenhouse B et al. Loss and dysfunction of Vδ2⁺ γδ T cells are associated with clinical tolerance to malaria. Sci. Transl. Med. 6(251), 251ra117 (2014).
  MedlineGoogle Scholar
• 16. Lautenbach MJ, Yman V, Silva CS et al. Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria. Cell Rep. 39(3), 110709 (2022).
  Medline CASGoogle Scholar
• 17. Portugal S, Moebius J, Skinner J et al. Exposure-dependent control of malaria-induced inflammation in children. PLoS Pathog. 10(4), e1004079 (2014).
  MedlineGoogle Scholar
• 18. Guha R, Mathioudaki A, Doumbo S et al. Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype. PLoS Pathog. 17(4), e1009430 (2021).
  Medline CASGoogle Scholar
• 19. Gardinassi LG, Arévalo-Herrera M, Herrera S et al. Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling. Redox. Biol. 17, 158–170 (2018).
  Medline CASGoogle Scholar
• 20. Vinhaes CL, Carmo TA, Queiroz ATL et al. Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation. PLoS Negl. Trop. Dis. 15(11), e0009886 (2021).
  Medline CASGoogle Scholar