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Preliminary Communication

Sertraline has fungicidal activity against Candida spp. and acts by inhibiting membrane and cell wall biosynthesis

    Daniel S Rodrigues

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    ,
    Vitória PF Cabral

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    ,
    Amanda D Barbosa

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    ,
    Lívia GA Valente Sá

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    ,
    Cecília R Silva

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    ,
    Lara EA Moreira

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    ,
    Joao BA Neto

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    ,
    Jacilene Silva

    Department of Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, Ceará, 930-000, Brazil

    ,
    Hélcio S Santos

    Science and Technology Center, Chemistry Course, Vale do Acaraú State University, CE, 040-370, Sobral

    ,
    Emmanuel S Marinho

    Department of Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, Ceará, 930-000, Brazil

    ,
    Bruno C Cavalcanti

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    ,
    Manoel O Moraes

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    &
    Hélio V Nobre Júnior

    *Author for correspondence: Tel.: +55 853 366 8274;

    E-mail Address: label_ufc@yahoo.com.br

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, 430-372, Brazil

    Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, 430-275, Brazil

    Published Online:https://doi.org/10.2217/fmb-2022-0254

    Aim: Our study evaluated the activity of sertraline (SER) alone and associated with antifungal drugs in planktonic Candida spp. strains, and investigated its mechanism of action. Materials & methods: Broth microdilution method and minimum fungicidal concentration/MIC ratio were used to assess SER anticandidal activity, and the interaction with antifungals was determined by fractional inhibitory concentration index. The mechanism of action was investigated by flow cytometry and in silico tests. Results: SER inhibited Candida spp. strains at low concentrations by the fungicidal effect and showed no loss of effectiveness when combined. Its action seemed to be related to the membrane and cell wall biosynthesis inhibition. Conclusion: SER has activity against Candida spp. isolated and associated with antifungals, and acts by causing cell wall and membrane damage.

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