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New compound probiotic beverage protects against antibiotic-associated diarrhea in mice by modulating the microbiota

    Yang Chen

    College of Food Science, South China Agricultural University, Guangzhou, Guangdong, 510640, China

    ,
    Siming Lu

    College of Food Science, South China Agricultural University, Guangzhou, Guangdong, 510640, China

    ,
    Zhiwei Ye

    College of Food Science, South China Agricultural University, Guangzhou, Guangdong, 510640, China

    ,
    Xin Cai

    College of Food Science, South China Agricultural University, Guangzhou, Guangdong, 510640, China

    ,
    Shanshan Wu

    College of Food Science, South China Agricultural University, Guangzhou, Guangdong, 510640, China

    ,
    Pan Li

    College of Food Science, South China Agricultural University, Guangzhou, Guangdong, 510640, China

    &
    Bing Du

    *Author for correspondence:

    E-mail Address: dubing@scau.edu.cn

    College of Food Science, South China Agricultural University, Guangzhou, Guangdong, 510640, China

    Published Online:https://doi.org/10.2217/fmb-2021-0240

    Probiotics and their products are the classic way to treat and prevent gastrointestinal diseases. In this study, the authors designed new combinations and doses of probiotic beverages for antibiotic-associated diarrhea. Group S1 was different from the other groups, including Lactobacillus rhamnosus HN001, Lactobacillus acidophilus NCFM and Bifidobacterium lactis BI-07. Its inulin content was higher than those of the other groups. Mice were induced with a 16-day administration of triple antibiotics in advance for 2 weeks prior to antibiotic treatment. In the experiment, the treatment group returned to normal more quickly than the placebo group. In group S1, the relative abundance of the phylum Firmicutes and genus Lactobacillus increased, and the structure of the microbiota was the closest to normal among all groups. In conclusion, the combinations of probiotic beverages effectively caused structural recovery of the gut and fecal microbiota against antibiotic-associated diarrhea, and the S1 formula showed the best efficacy.

    Graphical abstract

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