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Gallic acid leads to cell death of Candida albicans by the apoptosis mechanism

    Ito Liberato

    Department of Physics, Federal University of Ceará, Fortaleza, CE, Brazil

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    ,
    Leticia A Lino

    Department of Physics, Federal University of Ceará, Fortaleza, CE, Brazil

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    ,
    Juan KD Souza

    Department of Physics, Federal University of Ceará, Fortaleza, CE, Brazil

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    ,
    João BA Neto

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil

    Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

    ,
    Livia GAV Sá

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil

    Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

    ,
    Vitória PF Cabral

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil

    Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

    ,
    Cecília R Silva

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil

    Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

    ,
    Bruno C Cavalcanti

    Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

    Department of Physiology & Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil

    ,
    Manoel O Moraes

    Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

    Department of Physiology & Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil

    ,
    Valder N Freire

    Department of Physics, Federal University of Ceará, Fortaleza, CE, Brazil

    ,
    Hélio VN Júnior

    School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil

    Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, Brazil

    &
    Claudia R Andrade

    *Author for correspondence: Tel.: +55 853 265 8152;

    E-mail Address: label_ufc@yahoo.com

    Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil

    Published Online:https://doi.org/10.2217/fmb-2021-0139

    Aim: To evaluate the antifungal activity of gallic acid (GA) against the strains of Candida spp. resistant to fluconazole and to determine its mechanism of action. Materials & methods: Antifungal activity was evaluated using the broth microdilution and flow cytometry techniques. Results: GA presented minimum inhibitory concentrations ranging from 16 to 72 μg/ml, causing alterations of the membrane integrity and mitochondrial transmembrane potential, production of reactive oxygen species and externalization of phosphatidylserine. Conclusion: GA has potential antifungal activity against Candida spp.

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