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Antimicrobial susceptibility patterns of bacteria that commonly cause bacteremia at a tertiary hospital in Zambia

Maisa Kasanga

Zhengzhou University, College of Public Health, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China

University Teaching Hospitals, P/Bag RW1X, Lusaka, Zambia

,
Steward Mudenda

The University of Zambia, School of Health Sciences, Department of Pharmacy, PO Box 50110, Lusaka, Zambia

The University of Zambia, School of Veterinary Medicine, Department of Disease Control, PO Box 32379, Lusaka, Zambia

,
Makomani Siyanga

Zambia Medicines Regulatory Authority, Plot No. 2350/M, Off KK International Airport Road, PO Box 31890 Lusaka

,
Misheck Chileshe

Mary Begg Health Services, 56 Chintu Avenue, Northrise, PO Box 72221, Ndola

,
Mark J Mwiikisa

Lusaka Trust Hospital, Plot 2190, Nsumbu Rd, Woodlands, PO Box 35852, Lusaka Main, Lusaka, Zambia

,
Maika Kasanga

University Teaching Hospitals, P/Bag RW1X, Lusaka, Zambia

,
Benjamin B Solochi

University Teaching Hospitals, P/Bag RW1X, Lusaka, Zambia

,
Theodore Gondwe

Zhengzhou University, College of Public Health, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China

,
Timothy Kantenga

University Teaching Hospitals, P/Bag RW1X, Lusaka, Zambia

,
Aaron L Shibemba

University Teaching Hospitals, P/Bag RW1X, Lusaka, Zambia

Directorate of Clinical Pathology & Laboratory Services, Ministry of Health, Lusaka

,
Mwansa Chitalu

University Teaching Hospitals, P/Bag RW1X, Lusaka, Zambia

,
Ruth Nakazwe

University Teaching Hospitals, P/Bag RW1X, Lusaka, Zambia

&
Jian Wu

*Author for correspondence:

E-mail Address: wujian@zzu.edu.cn

Zhengzhou University, College of Public Health, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China

Published Online:https://doi.org/10.2217/fmb-2020-0250

Background: Bloodstream infections and antimicrobial resistance cause global increases in morbidity and mortality. Aim: We evaluated the antimicrobial susceptibility patterns of bacteria that commonly cause bacteremia in humans. Materials & methods: We conducted a retrospective cross-sectional study at the University Teaching Hospitals in Lusaka, Zambia, using Laboratory Information Systems. Results: The commonest isolated bacteria associated with sepsis were Klebsiella pneumoniae. The distribution of bacteria associated with bacteremia in different wards and departments at University Teaching Hospitals was statistically significant (χ2 = 1211.518; p < 0.001). Conclusion:K. pneumoniae, Escherichia coli, Pantoea agglomerans and Enterococcus species have developed high resistance levels against ampicillin, cefotaxime, ciprofloxacin, gentamicin and trimethoprim/sulfamethoxazole and a very low resistance levels against imipenem and Amikacin.

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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