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Cold-adapted bacterial extracts as a source of anti-infective and antimicrobial compounds against Staphylococcus aureus

    Marco Artini

    Department of Public Health & Infectious Diseases, Sapienza University, 00185 Rome, Italy

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Rosanna Papa

    Department of Public Health & Infectious Diseases, Sapienza University, 00185 Rome, Italy

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Gianluca Vrenna

    Department of Public Health & Infectious Diseases, Sapienza University, 00185 Rome, Italy

    ,
    Concetta Lauro

    Department of Chemical Sciences, Federico II University, 80126 Naples, Italy

    ,
    Annarita Ricciardelli

    Department of Chemical Sciences, Federico II University, 80126 Naples, Italy

    ,
    Angela Casillo

    Department of Chemical Sciences, Federico II University, 80126 Naples, Italy

    ,
    Maria M Corsaro

    Department of Chemical Sciences, Federico II University, 80126 Naples, Italy

    ,
    Maria L Tutino

    Department of Chemical Sciences, Federico II University, 80126 Naples, Italy

    ,
    Ermenegilda Parrilli

    Department of Chemical Sciences, Federico II University, 80126 Naples, Italy

    &
    Laura Selan

    *Author for correspondence: Tel.: +39 0649 694 261; Fax: +39 0649 694 298;

    E-mail Address: laura.selan@uniroma1.it

    Department of Public Health & Infectious Diseases, Sapienza University, 00185 Rome, Italy

    Published Online:https://doi.org/10.2217/fmb-2019-0147

    Aim: The dramatic emergence of antibiotic resistance has directed the interest of research toward the discovery of novel antimicrobial molecules. In this context, cold-adapted marine bacteria living in polar regions represent an untapped reservoir of biodiversity endowed with an interesting chemical repertoire. The aim of this work was to identify new antimicrobials and/or antibiofilm molecules produced by cold-adapted bacteria. Materials & methods: Organic extracts obtained from polar marine bacteria were tested against Staphylococcus aureus. Most promising samples were subjected to suitable purification strategies. Results: Results obtained led to the identification of a novel lipopeptide able to effectively inhibit the biofilm formation of S. aureus. Conclusion: New lipopeptide may be potentially useful in a wide variety of biotechnological and medical applications.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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