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Lower myocardial infarction and all-cause mortality with laparoscopic cholecystectomy compared with open cholecystectomy

University of Arizona, College of Medicine, Phoenix 85004, AZ, USA

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Mehrtash Hashemzadeh

University of Arizona, College of Medicine, Phoenix 85004, AZ, USA

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Mohammad Reza Movahed

*Author for correspondence: Tel.: +1 949 400 0091;

E-mail Address: rmova@aol.com

https://orcid.org/0000-0001-7492-0510

University of Arizona, College of Medicine, Phoenix 85004, AZ, USA

University of Arizona Sarver Heart Center, College of Medicine, Tucson 85724, AZ, USA

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Published Online:19 Dec 2023https://doi.org/10.2217/fca-2023-0102

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Abstract

Aim: We compared inpatient outcome data of open (OC) versus laparoscopic cholecystectomy (LC). Patients & methods: We used the National Inpatient Samples database from 2010–2014. Results: LC was done in 340,999 and OC in 68,529 OC patients. In 2010, ST-elevation myocardial infarction (STEMI) prevalence was 0.2 versus 0% (OR: 3.1, CI: 1.7–5.5; p < 0.001), non-STEMI 1 versus 0.4% (OR: 2.5 CI: 2.0–3.0; p < 0001), mortality 3.4 versus 0.4% (OR: 9.2, CI: 7.9–10.6; p < 0001). After multivariate adjustment, OC remained independently associated with STEMI, non-STEMI and all-cause inpatient mortality (mortality multivariate OR: 6.4, CI: 5.5–7.4; p < 0001, STEMI OR: 2.2. CI: 1.2–3.9; p = 0.007, non-STEMI OR: 1.5, CI: 1.3–1.9; p < 0001). Conclusion: OC is independently associated with STEMI, non-STEMI and all-cause inpatient mortality compared with LC.

Plain language summary

The gallbladder is a small, pouch-like organ in the upper right part of the stomach that stores bile, a fluid that helps break down fatty food. Gallbladder removal surgery can be performed laparoscopically, meaning it can be performed using a small incision with the help of a camera, instead of through a more invasive surgery called an open cholecystectomy where the removal takes place through a larger incision. In this study, we investigated if these two approaches have different risks of myocardial infraction, also known as heart attack. Our results show that using a laparoscopy has a lower association of myocardial infarction in patients undergoing gallbladder surgery.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 19, No. 16

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History

Received 9 August 2023

Accepted 2 November 2023

Published online 19 December 2023

Published in print December 2023

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Keywords

Author contributions

All authors had full access to study data and an active role in writing manuscript. T Keele: Writing the manuscript and conception of method and finding ICD codes. M Hashemzadeh: Performing statistical analysis and writing the manuscript. M Reza Movahed: Design the protocol and the study, writing, finding ICD codes.

Financial disclosure

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

NIS data base is publicly available for research and exempt by IRBs containing no identifying information. Approval from NIS database obtained by completing training module and passing the exam.

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