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Regenerative Medicine

Long-term prognosis in patients undergoing redo-isolated aortic valve replacement

    Aleksander Dokollari

    *Author for correspondence:

    E-mail Address: aleksanderdokollari2@gmail.com

    Cardiovascular Research Institute Maastricht - CARIM, Maastricht University Medical Centre, Maastricht, Netherlands

    Cardiac Surgery Department, St. Boniface Hospital, University of Manitoba, Winnipeg M3B1W7, Canada

    ,
    Gianluca Torregrossa

    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA

    ,
    Serge Sicouri

    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA

    ,
    Matteo Cameli

    Department of Medical Biotechnologies, Division of Cardiology, University Hospital of Siena, Siena, Italy

    ,
    Giulia Elena Mandoli

    Department of Medical Biotechnologies, Division of Cardiology, University Hospital of Siena, Siena, Italy

    ,
    Stephanie Kjelstrom

    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA

    ,
    Edvin Prifti

    Division of Cardiac Surgery University Hospital Center “Mother Teresa” Tirana Albania

    ,
    Altin Veshti

    Division of Cardiac Surgery University Hospital Center “Mother Teresa” Tirana Albania

    ,
    Massimo Bonacchi‡

    Department of Experimental & Clinical Medicine, University of Florence, Firenze, Italy

    ‡Authors contributed equally as senior authors

    Search for more papers by this author

    &
    Sandro Gelsomino‡

    Cardiovascular Research Institute Maastricht - CARIM, Maastricht University Medical Centre, Maastricht, Netherlands

    ‡Authors contributed equally as senior authors

    Search for more papers by this author

    Published Online:https://doi.org/10.2217/fca-2023-0050

    Aim: To evaluate clinical outcomes after redo aortic valve replacement (AVR) with sutured valves, versus valve-in-valve transcatheter aortic valve replacement (ViV-TAVR), versus sutureless valves. Methods: We identified 113 consecutive patients undergoing redo AVR with either ViV-TAVR, redo-sutured and redo-sutureless valves between August 2010 to March 2020. Heart-team made the decision whether patient should undergo redo-sutureless versus ViV-TAVR, versus redo-sutured AVR. Results: Preoperatively, redo-sutured (n = 57), ViV-TAVR (n = 31) and redo-sutureless (n = 25) patients were compared. Postoperatively, after propensity-adjustment analysis, the redo surgical aortic valve replacement group had a higher incidence of new postoperative atrial fibrillation (POAF; p = 0.04) compared with redo-sutureless group. Follow-up outcomes analysis did not show differences among groups. Conclusion: Patients undergoing redo-sutureless AVR experienced a higher incidence of POAF compared with patients undergoing redo-sutured.

    Graphical abstract

    Papers of special note have been highlighted as: •• of considerable interest

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