Abstract
We present a case of a 54-year-old gentleman with a history of hypertension and chronic HIV who presented with fever and epigastric pain, found to have elevated troponin-I levels and diffuse ST-segement elevations on ECG without clinical evidence of ischemia concerning for myopericarditis. Initial laboratory findings also included thrombocytopenia and elevated aminotransferases as well as computed tomography imaging revealing splenic infarcts. Given plausible exposure to ticks, this led to the eventual diagnosis of anaplasmosis confirmed on PCR assay. Cardiac MRI images confirmed myocardial involvement, which resolved with antibiotic treatment. While rare, cardiac involvement is possible sequelae of anaplasmosis infection as illustrated by this case.
Papers of special note have been highlighted as: • of interest; •• of considerable interest
References
- 1. . Severe anaplasmosis presenting as possible CVA: case report and 3-year anaplasma infection diagnosis data is based on PCR testing and serology. IDCases 24, e01073 (2021).
- 2. Human granulocytic anaplasmosis – a systematic review of published cases. Microorganisms 10(7), 1433 (2022).
- 3. . Human granulocytic anaplasmosis in the United States from 2008 to 2012: a summary of national surveillance data. Am. J. Trop. Med. Hyg. 93(1), 66–72 (2015). • Gives an overview of pathophysiology and epidemiology of anaplasmosis.
- 4. . Diagnosis and management of tickborne Rickettsial diseases: rocky mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis – United States. MMWR Recomm. Rep. 65(2), 1–44 (2016). • Gives an overview of management of anaplasmosis.
- 5. . Human granulocytic anaplasmosis. Infect. Dis. Clin. North Am. 22(3), 433–448 (2008).
- 6. . Human granulocytic anaplasmosis. Infect. Dis. Clin. North Am. 29(2), 341–355 (2015).
- 7. . Epidemiology of Lyme disease. Infect. Dis. Clin. North Am. 29(2), 187–210 (2015).
- 8. . Sinus bradycardia: can we blame ehrlichiosis? Am. J. Med. 128(1), e7–e8 (2015).
- 9. The early clinical manifestations of Lyme disease. Ann. Intern. Med. 99(1), 76–82 (1983).
- 10. . Human granulocytic anaplasmosis affecting the myocardium. J. Gen. Intern. Med. 20(10), C8–C10 (2005). •• Presents one of the very few reports of myocarditis with anaplasmosis.
- 11. . Myocardial involvement in a patient with human ehrlichiosis. Am. J. Med. 98(4), 414–415 (1995).
- 12. . Human monocytic ehrlichiosis associated with myocarditis and hemophagocytic lymphohistiocytosis. JACC Case Rep. 2(3), 420–425 (2020). • Presents cardiac involvement with ehrlichiosis, which has a similar presentation to anaplasmosis.
- 13. . Cardiac MRI in post COVID acute myocarditis: a case report. IDCases 29, e01579 (2022).
- 14. Influenza myopericarditis and pericarditis: a literature review. J. Clin. Med. 11(14), 4123 (2022).
- 15. Ministry of Health of Israel. Surveillance of myocarditis (inflammation of the heart muscle) cases between December 2020 and May 2021 (Including). Available at: www.gov.il/en/departments/news/01062021-03 (Accessed July 6, 2021).
- 16. . Myocarditis with COVID-19 mRNA vaccines. Circulation 144(6), 471–484 (2021).
- 17. . Pathology rounds: identifying human ehrlichiosis. Lab. Med. 27(6), 372–374 (1996).
- 18. Brief report: fatal seronegative ehrlichiosis in a patient with HIV infection. N. Engl. J. Med. 329(16), 1164–1167 (1993). • Presents a case reports of rapid progression of infection in patients with HIV and similar tickborne illness.
- 19. . HIV and myocarditis. Curr. Opin. HIV AIDS 12(6), 561–565 (2017).
- 20. A fatal case of Kaposi Sarcoma Immune Reconstitution Syndrome (KS-IRIS) complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) or Multicentric Castleman Disease (MCD): a case report and review. Am. J. Case Rep. 21, e926433 (2020).
- 21. . Splenic complications of Babesia microti infection in humans: a systematic review. Can. J. Infect. Dis. Med. Microbiol. 2020, e6934149 (2020).
- 22. . Babesiosis as a cause of atraumatic splenic injury: two case reports and a review of literature. J. Gen. Int. Med. 36(12), 3869–3874 (2021).
- 23. . Lessons learned for pathogenesis, immunology, and disease of erythrocytic parasites: plasmodium and Babesia. Front. Cell. Infect. Microbiol. 11, 685239 (2021).