We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Acute myopericarditis due to human granulocytic anaplasmosis

    Wojciech Rzechorzek

    *Author for correspondence: Tel.: +1 914 493 6608;

    E-mail Address: wojciech.rzechorzek@wmchealth.org

    Department of Cardiology, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    ,
    Dhrubajyoti Bandyopadhyay

    Department of Cardiology, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    ,
    Areen Pitaktong

    Department of Medicine, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    ,
    Pragya Ranjan

    Department of Cardiology, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    ,
    Anthon Fuisz

    Department of Cardiology, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    ,
    Marc Y El-Khoury

    Department of Medicine, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    ,
    Wilbert Aronow

    Department of Cardiology, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    &
    Stephen Pan

    Department of Cardiology, New York Medical College/Westchester Medical Center, 100 Woods Rd Valhalla, NY 10595, USA

    Published Online:https://doi.org/10.2217/fca-2023-0028

    We present a case of a 54-year-old gentleman with a history of hypertension and chronic HIV who presented with fever and epigastric pain, found to have elevated troponin-I levels and diffuse ST-segement elevations on ECG without clinical evidence of ischemia concerning for myopericarditis. Initial laboratory findings also included thrombocytopenia and elevated aminotransferases as well as computed tomography imaging revealing splenic infarcts. Given plausible exposure to ticks, this led to the eventual diagnosis of anaplasmosis confirmed on PCR assay. Cardiac MRI images confirmed myocardial involvement, which resolved with antibiotic treatment. While rare, cardiac involvement is possible sequelae of anaplasmosis infection as illustrated by this case.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

    References

    • 1. Eldaour Y, Hariri R, Yassin M. Severe anaplasmosis presenting as possible CVA: case report and 3-year anaplasma infection diagnosis data is based on PCR testing and serology. IDCases 24, e01073 (2021).
    • 2. Dumic I, Jevtic D, Veselinovic M et al. Human granulocytic anaplasmosis – a systematic review of published cases. Microorganisms 10(7), 1433 (2022).
    • 3. Dahlgren FS, Heitman KN, Drexler NA, Massung RF, Behravesh CB. Human granulocytic anaplasmosis in the United States from 2008 to 2012: a summary of national surveillance data. Am. J. Trop. Med. Hyg. 93(1), 66–72 (2015). • Gives an overview of pathophysiology and epidemiology of anaplasmosis.
    • 4. Biggs HM. Diagnosis and management of tickborne Rickettsial diseases: rocky mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis – United States. MMWR Recomm. Rep. 65(2), 1–44 (2016). • Gives an overview of management of anaplasmosis.
    • 5. Bakken JS, Dumler S. Human granulocytic anaplasmosis. Infect. Dis. Clin. North Am. 22(3), 433–448 (2008).
    • 6. Bakken JS, Dumler JS. Human granulocytic anaplasmosis. Infect. Dis. Clin. North Am. 29(2), 341–355 (2015).
    • 7. Mead PS. Epidemiology of Lyme disease. Infect. Dis. Clin. North Am. 29(2), 187–210 (2015).
    • 8. Shivamurthy P, Gowani SA, Mutneja R, Kukunoor S, Shah M, Stein R. Sinus bradycardia: can we blame ehrlichiosis? Am. J. Med. 128(1), e7–e8 (2015).
    • 9. Steere AC, Bartenhagen NH, Craft JE et al. The early clinical manifestations of Lyme disease. Ann. Intern. Med. 99(1), 76–82 (1983).
    • 10. Malik A, Jameel MN, Ali SS, Mir S. Human granulocytic anaplasmosis affecting the myocardium. J. Gen. Intern. Med. 20(10), C8–C10 (2005). •• Presents one of the very few reports of myocarditis with anaplasmosis.
    • 11. Williams JD, Snow RM, Arciniegas JG. Myocardial involvement in a patient with human ehrlichiosis. Am. J. Med. 98(4), 414–415 (1995).
    • 12. Dahm CN, Yang BQ, Clark DE, Armstrong WC, Stevenson LW. Human monocytic ehrlichiosis associated with myocarditis and hemophagocytic lymphohistiocytosis. JACC Case Rep. 2(3), 420–425 (2020). • Presents cardiac involvement with ehrlichiosis, which has a similar presentation to anaplasmosis.
    • 13. Neupane NP, Rajlawot K, Adhikari C, Kandel D, Mustafa I. Cardiac MRI in post COVID acute myocarditis: a case report. IDCases 29, e01579 (2022).
    • 14. Radovanovic M, Petrovic M, Barsoum MK et al. Influenza myopericarditis and pericarditis: a literature review. J. Clin. Med. 11(14), 4123 (2022).
    • 15. Ministry of Health of Israel. Surveillance of myocarditis (inflammation of the heart muscle) cases between December 2020 and May 2021 (Including). Available at: www.gov.il/en/departments/news/01062021-03 (Accessed July 6, 2021).
    • 16. Bozkurt B, Kamat I, Hotez PJ. Myocarditis with COVID-19 mRNA vaccines. Circulation 144(6), 471–484 (2021).
    • 17. Barenfanger J, Patel PG, Dumler JS, Walker DH. Pathology rounds: identifying human ehrlichiosis. Lab. Med. 27(6), 372–374 (1996).
    • 18. Paddock CD, Suchard DP, Grumbach KL et al. Brief report: fatal seronegative ehrlichiosis in a patient with HIV infection. N. Engl. J. Med. 329(16), 1164–1167 (1993). • Presents a case reports of rapid progression of infection in patients with HIV and similar tickborne illness.
    • 19. Ntusi NAB. HIV and myocarditis. Curr. Opin. HIV AIDS 12(6), 561–565 (2017).
    • 20. Dumic I, Radovanovic M, Igandan O et al. A fatal case of Kaposi Sarcoma Immune Reconstitution Syndrome (KS-IRIS) complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) or Multicentric Castleman Disease (MCD): a case report and review. Am. J. Case Rep. 21, e926433 (2020).
    • 21. Dumic I, Madrid C, Rueda Prada L, Nordstrom CW, Taweesedt PT, Ramanan P. Splenic complications of Babesia microti infection in humans: a systematic review. Can. J. Infect. Dis. Med. Microbiol. 2020, e6934149 (2020).
    • 22. Sung LH, Sundaram AH, Glick AL, Chen DF, Shipton L. Babesiosis as a cause of atraumatic splenic injury: two case reports and a review of literature. J. Gen. Int. Med. 36(12), 3869–3874 (2021).
    • 23. Djokic V, Rocha SC, Parveen N. Lessons learned for pathogenesis, immunology, and disease of erythrocytic parasites: plasmodium and Babesia. Front. Cell. Infect. Microbiol. 11, 685239 (2021).