Abstract
Takotsubo syndrome (TTS) is an increasingly diagnosed entity, however the underlying pathophysiological mechanisms and their clinical implications are incompletely understood. An 82-year-old female, diagnosed with pituitary apoplexy, presented with ECG abnormalities and hsTnI levels consistent with an acute coronary syndrome and therefore underwent urgent coronary angiography that showed no significant stenosis and apical ballooning at left ventricle angiogram and therefore a TTS diagnosis was made. Moreover, during catheterization a 20 s torsade de pointes was registered. TTS is an entity that can be triggered by numerous conditions. This case of TTS was linked to many neuroendocrinological disorders.
Papers of special note have been highlighted as: • of interest
References
- 1. International expert consensus document on Takotsubo syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur. Heart J. 39(22), 2032–2046 (2018). • Paramount importance for understanding Takotsubo syndrome pathophysiology, diagnosis and treatment.
- 2. . Takotsubo endocrinopathy. Eur. Endocrinol. 16(2), 97–99 (2020). • Highlights the link between this syndrome and endocrinological and neurological disorders.
- 3. . Takotsubo cardiomyopathy–acute cardiac dysfunction associated with neurological and psychiatric disorders. Front. Neurol. 10, 1–8 (2019). • Highlights the link between this syndrome and endocrinological and neurological disorders.
- 4. . Role of coronary microvascular dysfunction in Takotsubo cardiomyopathy. Circ. J. 80(2), 299–305 (2016).
- 5. Stress cardiomyopathy diagnosis and treatment: JACC state-of-the-art review. J. Am. Coll. Cardiol. 72(16), 1955–1971 (2018). • Paramount importance for understanding Takotsubo syndrome pathophysiology, diagnosis and treatment.
- 6. Endocrinological abnormalities and Takotsubo cardiomyopathy. Monaldi Arch. Chest. Dis. 91(2), 1–2 (2021).
- 7. Autoimmune polyendocrine syndrome II presenting paradoxically as Takotsubo cardiomyopathy: a case report and reappraisal of pathophysiology. Egypt. Heart J. 74(1), 74–82 (2022).
- 8. Association of endocrine conditions with Takotsubo cardiomyopathy: a comprehensive review. J. Am. Heart Assoc. 7(19), 1–19 (2018). • Highlights the link between this syndrome and endocrinological and neurological disorders.
- 9. Iatrogenic corticosteroids induced Takotsubo cardiomyopathy. Cardiovasc. Revasc. Med. 19(4), 471–473 (2018).
- 10. . An unusual trigger for stress cardiomyopathy. J. Med. Cases 9(12), 386–389 (2018).
- 11. Prevalence and clinical significance of life-threatening arrhythmias in Takotsubo cardiomyopathy. J. Am. Coll. Cardiol. 65(19), 2148–2150 (2015). • Fundamental in explaining the arrhythmic risk of these subjects.
- 12. Ventricular arrhythmias in patients with Takotsubo syndrome. J. Arrhythm. 34(4), 369–375 (2018). • Fundamental in explaining the arrhythmic risk of these subjects.
- 13. Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes. Heart Rhythm 8(4), 555–561 (2011). • Fundamental in explaining the arrhythmic risk of these subjects.
